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Barbadin
Axon 2774
CAS:
356568-70-2
Purity:
99%
- Soluble in DMSO
- MF: C19H15N3OS
- MW: 333.41
Description
Selective β-arrestin/β2-adaptin interaction inhibitor (IC50 values of 19.1 and 15.6 μM for β-arrestin1 and β-arrestin2, respectively). Barbadin blocks agonist-promoted endocytosis of the prototypical β2-adrenergic, V2-vasopressin and angiotensin-II type-1 receptors, but does not affect β-arrestin-independent (transferrin) or AP2-independent (endothelin-A) receptor internalization.
More Information
| Parent CAS No. | 356568-70-2 |
|---|---|
| Chemical Name | 3-Amino-5-(4-benzylphenyl)thieno[2,3-d]pyrimidin-4(3H)-one |
| SMILES | C1(C2C3C(=O)N(N)C=NC=3SC=2)C=CC(CC2C=CC=CC=2)=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C19H15N3OS/c20-22-12-21-18-17(19(22)23)16(11-24-18)15-8-6-14(7-9-15)10-13-4-2-1-3-5-13/h1-9,11-12H,10,20H2 |
| InChiKey | OCBXPCSXEQQADU-UHFFFAOYSA-N |
| CID | 727640 |
| Short Description | β-Arrestin/β2-Adaptin inhibitor |
