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AX-024 hydrochloride
Axon 2692
- Parent CAS: 1370544-73-2
Purity:
99%
- Soluble in water and DMSO
- MF: C21H22FNO2.HCl
- MW: 375.86
Description
AX-024 is a first-in-class inhibitor of T cell receptor (TCR). It is an orally available inhibitor of the TCR-Nck interaction that selectively inhibits TCR-triggered T cell activation (IC50 value 1nM). By modulating TCR signaling, the inhibitor prevented the development of psoriasis and asthma and furthermore, exerted along-lasting therapeutic effect in a model of autoimmune encephalomyelitis.
AX-024 hydrochloride is much more applicable as the water-soluble salt form of AX-024.
More Information
| Parent CAS No. | 1370544-73-2 |
|---|---|
| Chemical Name | 1-((4-(4-Fluorophenyl)-6-methoxy-2H-chromen-3-yl)methyl)pyrrolidine hydrochloride |
| SMILES | C1C(F)=CC=C(C2=C(CN3CCCC3)COC3C=CC(OC)=CC2=3)C=1.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C21H22FNO2.ClH/c1-24-18-8-9-20-19(12-18)21(15-4-6-17(22)7-5-15)16(14-25-20)13-23-10-2-3-11-23;/h4-9,12H,2-3,10-11,13-14H2,1H3;1H |
| InChiKey | DGBCIMPGYRVTPD-UHFFFAOYSA-N |
| CID | 129909862 |
| Short Description | T cell receptor inhibitor |
References
- A Borroto et al. First-in-class inhibitor of the T cell receptor for the treatment of autoimmune diseases. Sci Transl Med. 2016 Dec 21;8(370):370ra184.
- Richter, K., et al. Small molecule AX-024 reduces T cell proliferation independently of CD3ε-Nck1 interaction, which is governed by a domain-swap in the Nck1-SH3. 1 domain. J. Biol. Chem. 2020 April 21, jbc-RA120.
- List of publications using Ax-024 (Axon 2692) purchased from Axon Medchem
