List of publications using AS 1517499 (Axon 1992) purchased from Axon Medchem

(total 65 citations listed from 2014; updated MAY-2019) 

2019
Liu, J., Li, Y., Lu, Z., Gu, J., Liang, Y., Huang, E., ... & Yu, H. (2019). Deceleration of glycometabolism impedes IgG‐producing B‐cell‐mediated tumor elimination by targeting SATB 1. Immunology, 156(1), 56-68.
https://onlinelibrary.wiley.com/doi/abs/10.1111/imm.12998

Harris, A. J., Mirchandani, A. S., Lynch, R. W., Murphy, F., Delaney, L., Small, D., ... & Dickinson, R. S. (2019). IL4R Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo.
Harris, A. J., Mirchandani, A. S., Lynch, R. W., Murphy, F., Delaney, L., Small, D., ... & Dickinson, R. S. (2019). IL4Rα Signaling Abrogates Hypoxic Neutrophil Survival and Limits Acute Lung Injury Responses In Vivo. American journal of respiratory and critical care medicine, (ja).
Li, Y., Zhao, C., Liu, J., Lu, Z., Lu, M., Gu, J., & Liu, R. (2019). CD1d highly expressed on DCs reduces lung tumor burden by enhancing antitumor immunity. Oncology reports, 41(5), 2679-2688.
Sharba, S., Navabi, N., Padra, M., Persson, J. A., Quintana-Hayashi, M. P., Gustafsson, J. K., ... & Quiding-Järbrink, M. (2019). Interleukin 4 induces rapid mucin transport, increases mucus thickness and quality and decreases colitis and Citrobacter rodentium in contact with epithelial cells. Virulence, 10(1), 97-117.
Miller, M. M., Barik, S., Cattin-Roy, A. N., Ukah, T. K., Hoeman, C. M., & Zaghouani, H. (2019). A New IRF-1–Driven Apoptotic Pathway Triggered by IL-4/IL-13 Kills Neonatal Th1 Cells and Weakens Protection against Viral Infection. The Journal of Immunology, ji1800943.
2018
Раецкая, А. А., Калиш, С. В., Лямина, С. В., Малышева, Е. В., Буданова, О. П., Бахтина, Л. Ю., & Малышев, И. Ю. (2018). Репрограммированые in vitro на м3 фенотип макрофаги останавливают рост солидной карциномы in vivo. Патологическая физиология и экспериментальная терапия, 62(1), 41-46.
* S3I204 and AS1517499 from Axon Medchem

Ni, X., Fu, B., Zhang, J., Sun, R. U. I., Tian, Z., & Wei, H. (2018). Cytokine-Based Generation of CD49a+ Eomes−/+ Natural Killer Cell Subsets. Frontiers in immunology, 9.
SOHN, Ki Young; KIM, Jae Wha. Method for treating paroxysmal nocturnal hemoglobinuria. U.S. Patent Application No 15/775,810, 2018.
SOHN, Ki Young; KIM, Jae Wha. Method for treating hemolytic uremic syndrome. U.S. Patent Application No 15/775,811, 2018.
Jacobs, J. R., Greiner, S. P., & Bowdridge, S. A. (2018). Impaired interleukin‐4 signalling promotes establishment of Haemonchus contortus in sheep. Parasite immunology, 40(12), e12597.
https://onlinelibrary.wiley.com/doi/abs/10.1111/pim.12597

Mitamura, Y., Nunomura, S., Nanri, Y., Arima, K., Yoshihara, T., Komiya, K., ... & Izuhara, K. (2018). Hierarchical control of IL-13 signals in lung fibroblasts by STAT6 and SOX11. Journal of Biological Chemistry, jbc-RA117.
http://www.jbc.org/content/early/2018/08/03/jbc.RA117.001364.short

Kim, M. J., Lee, Y. J., Yoon, Y. S., Lim, J. H., Park, E. M., Chong, Y. H., & Kang, J. L. (2018). A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPARγ. Cellular Physiology and Biochemistry, 45(5), 1863-1877.
https://www.karger.com/Article/Abstract/487877

Sun, H., Bi, J., Lei, Q., Wan, X., Jiang, T., Wu, C., & Wang, X. (2018). Partial enteral nutrition increases intestinal sIgA levels in mice undergoing parenteral nutrition in a dose-dependent manner. International Journal of Surgery, 49, 74-79.
https://www.sciencedirect.com/science/article/pii/S174391911731484X 
 
Kim, M. J., Lee, Y. J., Yoon, Y. S., Kim, M., Choi, J. H., Kim, H. S., & Kang, J. L. (2018). Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR‐γ expression and activation in macrophages. Journal of leukocyte biology, 103(5), 885-895.
https://jlb.onlinelibrary.wiley.com/doi/abs/10.1002/JLB.2A0817-341RR

Hamid, M. A., Jackson, R. J., Roy, S., Khanna, M., & Ranasinghe, C. (2018). Unexpected involvement of IL‐13 signalling via a STAT6 independent mechanism during murine IgG2a development following viral vaccination. European journal of immunology.
https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201747463
 
Makita, K., Mikami, Y., Matsuzaki, H., Miyashita, N., Takeshima, H., Noguchi, S., ... & Nagase, T. (2018). Mechanism of Periostin Production in Human Bronchial Smooth Muscle Cells. International archives of allergy and immunology, 175(1-2), 26-35.
https://www.karger.com/Article/Abstract/485892

Casella, G., Colombo, F., Finardi, A., Descamps, H., Ill-Raga, G., Spinelli, A., ... & Furlan, R. (2018). Extracellular Vesicles Containing IL-4 Modulate Neuroinflammation in a Mouse Model of Multiple Sclerosis. Molecular Therapy.
https://www.sciencedirect.com/science/article/pii/S1525001618303101

Hosokawa, Y., Hosokawa, I., Ozaki, K., & Matsuo, T. (2018). Transforming growth factor‐β1 increases C‐C chemokine ligand 11 production in interleukin 4‐stimulated human periodontal ligament cells. Cell biology international.
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.11030

QUAIL, Daniela Francis; JOYCE, Johanna Alexandra; BOWMAN, Robert Lyle. Compositions and methods for treatment of glioma. U.S. Patent Application No 15/572,456, 2018.
https://patents.google.com/patent/US20180125852A1/en

Ge, X. N., Bastan, I., Dileepan, M., Greenberg, Y., Ha, S. G., Steen, K. A., ... & Sriramarao, P. (2018). FABP4 regulates eosinophil recruitment and activation in allergic airway inflammation. American Journal of Physiology-Lung Cellular and Molecular Physiology.
https://www.physiology.org/doi/abs/10.1152/ajplung.00429.2017

Liang, Y., Yi, P., Yuan, D. M. K., Jie, Z., Kwota, Z., Soong, L., ... & Sun, J. (2018). IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis. Cellular & molecular immunology.
https://www.nature.com/articles/cmi2017147.pdf?origin=ppub

Ladjemi, M. Z., Gras, D., Dupasquier, S., Detry, B., Lecocq, M., Garulli, C., ... & Pilette, C. (2018). Bronchial Epithelial IgA Secretion Is Impaired in Asthma. Role of IL-4/IL-13. American journal of respiratory and critical care medicine, 197(11), 1396-1409.
https://www.atsjournals.org/doi/abs/10.1164/rccm.201703-0561OC

2017
Wei, X., Nie, S., Liu, H., Sun, J., Liu, J., Li, J., ... & Sun, Y. (2017). Angiopoietin-like protein 2 facilitates non-small cell lung cancer progression by promoting the polarization of M2 tumor-associated macrophages. American journal of cancer research, 7(11), 2220.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714751/

Калиш, С. В., Лямина, С. В., Раецкая, А. А., & Малышев, И. Ю. (2017). Репрограммированные М1 макрофаги с ингибированными STAT3, STAT6 и SMAD3 увеличивают продолжительность жизни мышей c экспериментальной карциномой. Патологическая физиология и экспериментальная терапия, 61(2), 4-9.
https://j.iph.ras.ru/index.php/pfiet/article/view/388

 Калиш, С. В., Лямина, С. В., Раецкая, А. А., Буданова, О. П., & Малышев, И. Ю. (2017). Программирование противоопухолевого иммунного ответа in vitro и его использование для остановки пролиферации опухолевых клеток и увеличения продолжительности жизни мышей с карциномой in vivo. Патологическая физиология и экспериментальная терапия, 61(4), 67-73.
* S3I 204 and AS1517499 were purchased from Axon Medchem
 
Hall, B. M., Balan, V., Gleiberman, A. S., Strom, E., Krasnov, P., Virtuoso, L. P., ... & Leonova, K. I. (2017). p16 (Ink4a) and senescence-associated β-galactosidase can be induced in macrophages as part of a reversible response to physiological stimuli. Aging (Albany NY), 9(8), 1867.
 
Meng, Y. H., Zhou, W. J., Jin, L. P., Liu, L. B., Chang, K. K., Mei, J., ... & Li, M. Q. (2017). RANKL-mediated harmonious dialogue between fetus and mother guarantees smooth gestation by inducing decidual M2 macrophage polarization. Cell death & disease, 8(10), e3105.
 
Bao, L., Mohan, G. C., Alexander, J. B., Doo, C., Shen, K., Bao, J., & Chan, L. S. (2017). A molecular mechanism for IL-4 suppression of loricrin transcription in epidermal keratinocytes: implication for atopic dermatitis pathogenesis. Innate immunity, 23(8), 641-647.
 
Harusato, A., Abo, H., Ngo, V. L., Yi, S. W., Mitsutake, K., Osuka, S., ... & Denning, T. L. (2017). IL-36γ signaling controls the induced regulatory T cell–Th9 cell balance via NFκB activation and STAT transcription factors. Mucosal immunology, 10(6), 1455.
 
Kälin, S., Becker, M., Ott, V. B., Serr, I., Hosp, F., Mollah, M. M., ... & Scherm, M. G. (2017). A Stat6/Pten axis links regulatory T cells with adipose tissue function. Cell metabolism, 26(3), 475-492.
 
Barik, S., Miller, M. M., Cattin-Roy, A. N., Ukah, T. K., Chen, W., & Zaghouani, H. (2017). IL-4/IL-13 Signaling Inhibits the Potential of Early Thymic Progenitors To Commit to the T Cell Lineage. The Journal of Immunology, ji1700498.
 
Miller, M. M. (2017). Interferon regulatory factor 1 (IRF-1) directs IL-4/IL-13 induced death of neonatal Th1 cells (Doctoral dissertation).
 
Binnemars-Postma, K., Bansal, R., Storm, G., & Prakash, J. (2017). Targeting the Stat6 pathway in tumor-associated macrophages reduces tumor growth and metastatic niche formation in breast cancer. The FASEB Journal, 32(2), 969-978.
 
Yoon, H., & Ko, Y. H. (2017). LMP1+ SLAMF1high cells are associated with drug resistance in Epstein-Barr virus-positive Farage cells. Oncotarget, 8(15), 24621.
(*Ruxolitinib, lenalidomide, AS1517499 from Axon Medchem)
 
Kalish, S., Lyamina, S., Manukhina, E., Malyshev, Y., Raetskaya, A., & Malyshev, I. (2017). M3 Macrophages Stop Division of Tumor Cells In Vitro and Extend Survival of Mice with Ehrlich Ascites Carcinoma. Medical science monitor basic research, 23, 8-19.
(*Stat3 inhibitor S3I204 and Stat6 inhibitor AS1517499 from Axon Medchem)
 
Nappo, G., Handle, F., Santer, F. R., McNeill, R. V., Seed, R. I., Collins, A. T., ... & Erb, H. H. H. (2017). The immunosuppressive cytokine interleukin-4 increases the clonogenic potential of prostate stem-like cells by activation of STAT6 signalling. Oncogenesis, 6(5), e342.

Leon-Cabrera, S. A., Molina-Guzman, E., Delgado-Ramirez, Y. G., Vázquez-Sandoval, A., Ledesma-Soto, Y., Pérez-Plasencia, C. G., ... & Ávila-Moreno, F. (2017). Lack of STAT6 attenuates inflammation and drives protection against early steps of colitis-associated colon cancer. Cancer Immunology Research, 5(5), 385-396.

Aravamudan, B., Goorhouse, K. J., Unnikrishnan, G., Thompson, M. A., Pabelick, C. M., Hawse, J. R., ... & Sathish, V. (2017). Differential Expression of Estrogen Receptor Variants in Response to Inflammation Signals in Human Airway Smooth Muscle. Journal of cellular physiology, 232(7), 1754-1760.

Philip, K., Mills, T. W., Davies, J., Chen, N. Y., Karmouty-Quintana, H., Luo, F., ... & Eltzschig, H. K. (2017). HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis. The FASEB Journal, fj-201700219R.
 
Waqas, S. F. H., Hoang, A. C., Lin, Y. T., Ampem, G., Azegrouz, H., Balogh, L., ... & Lim, J. S. (2017). Neuropeptide FF increases M2 activation and self-renewal of adipose tissue macrophages. The Journal of Clinical Investigation, 127(7).
https://www.jci.org/articles/view/90152

2016
Jiang, X., Zha, B., Liu, X., Liu, R., Liu, J., Huang, E., ... & Wang, L. (2016). STAT6 deficiency ameliorates Graves' disease severity by suppressing thyroid epithelial cell hyperplasia. Cell death & disease, 7(12), e2506.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260978/
 
Cheng, E., Zhang, X., Wilson, K. S., Wang, D. H., Park, J. Y., Huo, X., ... & Souza, R. F. (2016). JAK-STAT6 pathway inhibitors block eotaxin-3 secretion by epithelial cells and fibroblasts from esophageal eosinophilia patients: promising agents to improve inflammation and prevent fibrosis in EoE. PloS one, 11(6), e0157376.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157376

Quail, D. F., Bowman, R. L., Akkari, L., Quick, M. L., Schuhmacher, A. J., Huse, J. T., ... & Joyce, J. A. (2016). The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science, 352(6288), aad3018.
http://science.sciencemag.org/content/352/6288/aad3018.full

Higuchi, H., Shoji, T., Murase, Y., Iijima, S., & Nishijima, K. I. (2016). Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264. Bioscience, biotechnology, and biochemistry, 80(3), 501-509.

Saito, Y., Azuma, A., Matsuda, K., Kamio, K., Abe, S., & Gemma, A. (2016). Pirfenidone exerts a suppressive effect on CCL18 expression in U937-derived macrophages partly by inhibiting STAT6 phosphorylation. Immunopharmacology and immunotoxicology, 38(6), 464-471.
http://www.tandfonline.com/doi/abs/10.1080/08923973.2016.1247852

Quail, D. F., Bowman, R. L., Akkari, L., Quick, M. L., Schuhmacher, A. J., Huse, J. T., ... & Joyce, J. A. (2016). The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science, 352(6288), aad3018.
http://science.sciencemag.org/content/352/6288/aad3018 

Hosokawa, Y., Hosokawa,I., Shindo, S., Ozaki, K., & Matsuo, T. (2016). IL-4 ModulatesCCL11 andCCL20 Productions from IL-1β-Stimulated Human Periodontal Ligament Cells. Cellular Physiology and Biochemistry, 38(1), 153-159.
http://www.karger.com/Article/Abstract/438617 

Jeong, J., Kim, Y. J., Yoon, S. Y., Kim, Y. J., Kim, J. H., Sohn, K. Y., ... & Kim, J. W. (2016). PLAG (1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol) modulates eosinophil chemotaxis by regulatingCCL26 expression from epithelial cells. PloS one, 11(3), e0151758.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151758 

Han, Y. H., Chong, S., Sohn, K. Y., Kim, M. H., & Kim, J. W. (2016). "METHODS FOR TREATING LEUKOPENIA AND THROMBOCYTOPENIA." U.S.Patent No. 20,160,128,966.Washington,DC:U.S.Patent and Trademark Office.
http://www.freepatentsonline.com/y2016/0128966.html 

Aguilar-Hernandez, M. M., Blunt, M. D., Dobson, R., Yeomans, A., Thirdborough, S., Larrayoz, M., ... & Johnson, P. M. (2016). IL-4 enhances expression and function of surface IgM inCLLcells. Blood, blood-2015.
http://www.bloodjournal.org/content/early/2016/03/21/blood-2015-11-682906.abstract 

2015
Kouchi, Z. (2015). Monoacylglycerol lipase promotes Fcγ receptor-mediated phagocytosis in microglia but does not regulate LPS-induced upregulation of inflammatory cytokines. Biochemical and biophysical research communications, 464(2), 603-610.

http://www.sciencedirect.com/science/article/pii/S0006291X15302503
*AS1517499 and 10058-F4 from Axon Medchem 

Kiguchi, N., Kobayashi, Y., Saika, F., Sakaguchi, H., Maeda, T., & Kishioka, S. (2015). Peripheral interleukin-4 ameliorates inflammatory macrophage-dependent neuropathic pain. Pain, 156(4), 684-693.
http://journals.lww.com/pain/Abstract/2015/04000/Peripheral_interleukin_4_ameliorates_inflammatory.15.aspx 

Yoon, S. Y., Kang, H. B., Ko, Y. E., Shin, S. H., Kim, Y. J., Sohn, K. Y., ... & Kim, J. W. (2015). 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) Modulates Th2 Immunity through Attenuation of IL-4 Expression. Immune network, 15(2), 100-109.
http://synapse.koreamed.org/search.php?where=aview&id=10.4110/in.2015.15.2.100&code=0078IN&vmode=FULL 

Villa, A., Rizzi, N., Vegeto, E., Ciana, P., & Maggi, A. (2015). Estrogen accelerates the resolution of inflammation in macrophagic cells. Scientific reports, 5.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609992/ 

Geskin, L. J., Viragova, S., Stolz, D. B., & Fuschiotti, P. (2015). Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation. Blood, 125(18), 2798-2805.
http://www.bloodjournal.org/content/125/18/2798.abstract 

Kumar, R., Mickael, C., Chabon, J., Gebreab, L., Rutebemberwa, A., Garcia, A. R., ... & Barthel, L. (2015). The causal role of IL-4 and IL-13 in Schistosoma mansoni pulmonary hypertension. American journal of respiratory and critical care medicine, 192(8), 998-1008.
https://scholar.google.nl/scholar?q=as1517499+axon+medchem&hl=en&as_sdt=0%2C5&as_ylo=2015&as_yhi=2015# 

Higuchi, H., Shoji, T., Murase, Y., Iijima, S., & Nishijima, K. I. (2015). Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264. Bioscience, biotechnology, and biochemistry, 1-9.
http://www.tandfonline.com/doi/abs/10.1080/09168451.2015.1104238 

Dames, P., Bergann, T., Fromm, A., Bücker, R., Barmeyer, C., Krug, S. M., ... & Schulzke, J. D. (2015). Interleukin‐13 affects the epithelial sodium channel in the intestine by coordinated modulation ofSTAT6 and p38 MAPK activity. The Journal of Physiology, 593(24), 5269-5282.
http://onlinelibrary.wiley.com/doi/10.1113/JP271156/full 

Su, S., Zhao, Q., He, C., Huang, D., Liu, J., Chen, F., ... &Yao, H. (2015). miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program. Nature communications, 6.
http://www.nature.com/ncomms/2015/151005/ncomms9523/full/ncomms9523.html 

2014
Volpe, E., Pattarini, L., Martinez-Cingolani, C., Meller, S., Donnadieu, M. H., Bogiatzi, S.I., ... & Paronetto, M. P. (2014). Thymic stromal lymphopoietin links keratinocytes and dendritic cell–derived IL-23 in patients with psoriasis. Journal of Allergy and Clinical Immunology, 134(2), 373-381.http://www.sciencedirect.com/science/article/pii/S0091674914005971 

Ferreira, R., Lively, S., & Schlichter, L. C. (2014). IL-4 type 1 receptor signaling up-regulates KCNN4 expression, and increases the KCa3. 1 current and its contribution to migration of alternative-activated microglia. Front Cell Neurosci, 8(183.10), 3389.
http://file2.selleck.jp/citations/tofacitinib-Fedratinib-Front-Cell-Neurosci-20140822.pdf 

Hui, C. C. K., Murphy, D. M., Neighbour, H., Al‐Sayegh, M., O'Byrne, S., Thong, B., ... & Larché, M. (2014). T cell‐mediated induction of thymic stromal lymphopoietin in differentiated human primary bronchial epithelial cells. Clinical & Experimental Allergy, 44(7), 953-964.
http://onlinelibrary.wiley.com/doi/10.1111/cea.12330/full 

Roh, K. B., Kim,I.H., Kim, Y. S., Lee, M., Lee, J. A., Jung, E., & Park, D. (2014). Synephrine inhibits eotaxin-1 expression via theSTAT6 signaling pathway. Molecules, 19(8), 11883-11895.
http://www.mdpi.com/1420-3049/19/8/11883/htm 

John, L. (2014). Mechanismen der Transzytose von Makromolekülen bei Morbus Crohn: Untersuchungen am Zellmodell T84 und an humanen Kolon-Biopsien (Doctoral dissertation, Freie UniversitätBerlin).
http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000097497?lang=de 

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