List of publications using AS 1517499 (Axon 1992) purchased from Axon Medchem
(Total 91 citations listed from 2014; updated up to June 2022)
2022
Fang, F., Cao, W., Mu, Y., Okuyama, H., Li, L., Qiu, J., ... & Goronzy, J. J. (2022). IL-4 prevents adenosine-mediated immunoregulation by inhibiting CD39 expression. JCI Insight, 7(12).
https://insight.jci.org/articles/view/157509
Lee, Y. J., Kim, K., Kim, M., Ahn, Y. H., & Kang, J. L. (2022). Inhibition of STAT6 Activation by AS1517499 Inhibits Expression and Activity of PPARγ in Macrophages to Resolve Acute Inflammation in Mice. Biomolecules, 12(3), 447.
https://www.mdpi.com/2218-273X/12/3/447/htm
https://www.mdpi.com/2218-273X/12/3/447
Hara, T., Kasagi, Y., Wang, J., Sasaki, M., Aaron, B., Karami, A., ... & Muir, A. B. (2022). CD73+ Epithelial Progenitor Cells That Contribute to Homeostasis and Renewal Are Depleted in Eosinophilic Esophagitis. Cellular and Molecular Gastroenterology and Hepatology, 13(5), 1449-1467.
https://www.sciencedirect.com/science/article/pii/S2352345X22000182
2021
Kimura, S., Noguchi, H., Nanbu, U., & Nakayama, T. (2021). Macrophage CCL22 expression promotes lymphangiogenesis in patients with tongue squamous cell carcinoma via IL-4/STAT6 in the tumor microenvironment. Oncology Letters, 21(5), 1-11.
https://www.spandidos-publications.com/10.3892/ol.2021.12644
Li, P., Li, X., Deng, P., Wang, D., Bai, X., Li, Y., ... & Yi, B. (2021). Activation of adenosine A3 receptor reduces early brain injury by alleviating neuroinflammation after subarachnoid hemorrhage in elderly rats. Aging (Albany Ny), 13(1), 694.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7835045/
Dumigan, A., Cappa, O., Morris, B., Calderon-Gonzalez, R., Mills, G., Lancaster, R., ... & Bengoechea, J. A. (2021). In vivo single cell transcriptomics reveals Klebsiella pneumoniae rewiring of lung macrophages to promote infection. bioRxiv.
https://www.biorxiv.org/content/10.1101/2021.10.18.464784v1.full
Li, S., olde Heuvel, F., Rehman, R., Li, Z., Aousji, O., Froehlich, A., ... & Roselli, F. (2021). Interleukin-13 and its receptor are synaptic proteins involved in plasticity and neuroprotection. bioRxiv.
https://www.biorxiv.org/content/10.1101/2021.12.01.470746v1.full
Wu, W. J., Wang, S. H., Wu, C. C., Su, Y. A., Chiang, C. Y., Lai, C. H., ... & Lee, Y. J. (2021). IL-4 and IL-13 Promote Proliferation of Mammary Epithelial Cells through STAT6 and IRS-1. International journal of molecular sciences, 22(21), 12008.
https://www.mdpi.com/1422-0067/22/21/12008/htm
Jiao, B., An, C., Tran, M., Du, H., Wang, P., Zhou, D., & Wang, Y. (2021). Pharmacological Inhibition of STAT6 Ameliorates Myeloid Fibroblast Activation and Alternative Macrophage Polarization in Renal Fibrosis. Frontiers in Immunology, 12. 735014.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8426438/
Deimel, L. P., Li, Z., Roy, S., & Ranasinghe, C. (2021). STAT3 determines IL-4 signalling outcomes in naïve T cells. Scientific reports, 11(1), 1-14.
https://www.nature.com/articles/s41598-021-89860-7
* both Stattic and AS1517499 from Axon Medchem
Chu, K. H., Lin, S. Y., & Chiang, B. L. (2021). STAT6 Pathway Is Critical for the Induction and Function of Regulatory T Cells Induced by Mucosal B Cells. Frontiers in immunology, 3651.
https://www.frontiersin.org/articles/10.3389/fimmu.2020.615868/full
2020
Portales-Cervantes, L., Crump, O. M., Dada, S., Liwski, C. R., Gotovina, J., Haidl, I. D., & Marshall, J. S. (2020). IL-4 enhances interferon production by virus-infected human mast cells. Journal of Allergy and Clinical Immunology, 146(3), 675-677.
https://www.jacionline.org/article/S0091-6749(20)30264-5/fulltext
* Both AS1517499 and NT157 from Axon Medchem
2019
Liu, L., Zhu, X., Zhao, T., Yu, Y., Xue, Y., & Zou, H. (2019). Sirt1 ameliorates monosodium urate crystal–induced inflammation by altering macrophage polarization via the PI3K/Akt/STAT6 pathway. Rheumatology, 58(9), 1674-1683.
https://academic.oup.com/rheumatology/article/58/9/1674/5491522?login=true
Liu, J., Li, Y., Lu, Z., Gu, J., Liang, Y., Huang, E., ... & Yu, H. (2019). Deceleration of glycometabolism impedes IgG‐producing B‐cell‐mediated tumor elimination by targeting SATB 1. Immunology, 156(1), 56-68.
https://onlinelibrary.wiley.com/doi/abs/10.1111/imm.12998
Mitamura, Y., Nunomura, S., Nanri, Y., Arima, K., Yoshihara, T., Komiya, K., ... & Izuhara, K. (2018). Hierarchical control of IL-13 signals in lung fibroblasts by STAT6 and SOX11. Journal of Biological Chemistry, jbc-RA117.
http://www.jbc.org/content/early/2018/08/03/jbc.RA117.001364.short
Kim, M. J., Lee, Y. J., Yoon, Y. S., Lim, J. H., Park, E. M., Chong, Y. H., & Kang, J. L. (2018). A STAT6 Inhibitor AS1517499 Reduces Preventive Effects of Apoptotic Cell Instillation on Bleomycin-Induced Lung Fibrosis by Suppressing PPARγ. Cellular Physiology and Biochemistry, 45(5), 1863-1877.
https://www.karger.com/Article/Abstract/487877
Sun, H., Bi, J., Lei, Q., Wan, X., Jiang, T., Wu, C., & Wang, X. (2018). Partial enteral nutrition increases intestinal sIgA levels in mice undergoing parenteral nutrition in a dose-dependent manner. International Journal of Surgery, 49, 74-79.
https://www.sciencedirect.com/science/article/pii/S174391911731484X
Kim, M. J., Lee, Y. J., Yoon, Y. S., Kim, M., Choi, J. H., Kim, H. S., & Kang, J. L. (2018). Apoptotic cells trigger the ABCA1/STAT6 pathway leading to PPAR‐γ expression and activation in macrophages. Journal of leukocyte biology, 103(5), 885-895.
https://jlb.onlinelibrary.wiley.com/doi/abs/10.1002/JLB.2A0817-341RR
Hamid, M. A., Jackson, R. J., Roy, S., Khanna, M., & Ranasinghe, C. (2018). Unexpected involvement of IL‐13 signalling via a STAT6 independent mechanism during murine IgG2a development following viral vaccination. European journal of immunology.
https://onlinelibrary.wiley.com/doi/abs/10.1002/eji.201747463
Makita, K., Mikami, Y., Matsuzaki, H., Miyashita, N., Takeshima, H., Noguchi, S., ... & Nagase, T. (2018). Mechanism of Periostin Production in Human Bronchial Smooth Muscle Cells. International archives of allergy and immunology, 175(1-2), 26-35.
https://www.karger.com/Article/Abstract/485892
Casella, G., Colombo, F., Finardi, A., Descamps, H., Ill-Raga, G., Spinelli, A., ... & Furlan, R. (2018). Extracellular Vesicles Containing IL-4 Modulate Neuroinflammation in a Mouse Model of Multiple Sclerosis. Molecular Therapy.
https://www.sciencedirect.com/science/article/pii/S1525001618303101
Hosokawa, Y., Hosokawa, I., Ozaki, K., & Matsuo, T. (2018). Transforming growth factor‐β1 increases C‐C chemokine ligand 11 production in interleukin 4‐stimulated human periodontal ligament cells. Cell biology international.
https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.11030
QUAIL, Daniela Francis; JOYCE, Johanna Alexandra; BOWMAN, Robert Lyle. Compositions and methods for treatment of glioma. U.S. Patent Application No 15/572,456, 2018.
https://patents.google.com/patent/US20180125852A1/en
Ge, X. N., Bastan, I., Dileepan, M., Greenberg, Y., Ha, S. G., Steen, K. A., ... & Sriramarao, P. (2018). FABP4 regulates eosinophil recruitment and activation in allergic airway inflammation. American Journal of Physiology-Lung Cellular and Molecular Physiology.
https://www.physiology.org/doi/abs/10.1152/ajplung.00429.2017
Liang, Y., Yi, P., Yuan, D. M. K., Jie, Z., Kwota, Z., Soong, L., ... & Sun, J. (2018). IL-33 induces immunosuppressive neutrophils via a type 2 innate lymphoid cell/IL-13/STAT6 axis and protects the liver against injury in LCMV infection-induced viral hepatitis. Cellular & molecular immunology.
https://www.nature.com/articles/cmi2017147.pdf?origin=ppub
Ladjemi, M. Z., Gras, D., Dupasquier, S., Detry, B., Lecocq, M., Garulli, C., ... & Pilette, C. (2018). Bronchial Epithelial IgA Secretion Is Impaired in Asthma. Role of IL-4/IL-13. American journal of respiratory and critical care medicine, 197(11), 1396-1409.
https://www.atsjournals.org/doi/abs/10.1164/rccm.201703-0561OC
2017
Wei, X., Nie, S., Liu, H., Sun, J., Liu, J., Li, J., ... & Sun, Y. (2017). Angiopoietin-like protein 2 facilitates non-small cell lung cancer progression by promoting the polarization of M2 tumor-associated macrophages. American journal of cancer research, 7(11), 2220.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5714751/
Калиш, С. В., Лямина, С. В., Раецкая, А. А., & Малышев, И. Ю. (2017). Репрограммированные М1 макрофаги с ингибированными STAT3, STAT6 и SMAD3 увеличивают продолжительность жизни мышей c экспериментальной карциномой. Патологическая физиология и экспериментальная терапия, 61(2), 4-9.
https://j.iph.ras.ru/index.php/pfiet/article/view/388
Leon-Cabrera, S. A., Molina-Guzman, E., Delgado-Ramirez, Y. G., Vázquez-Sandoval, A., Ledesma-Soto, Y., Pérez-Plasencia, C. G., ... & Ávila-Moreno, F. (2017). Lack of STAT6 attenuates inflammation and drives protection against early steps of colitis-associated colon cancer. Cancer Immunology Research, 5(5), 385-396.
Aravamudan, B., Goorhouse, K. J., Unnikrishnan, G., Thompson, M. A., Pabelick, C. M., Hawse, J. R., ... & Sathish, V. (2017). Differential Expression of Estrogen Receptor Variants in Response to Inflammation Signals in Human Airway Smooth Muscle. Journal of cellular physiology, 232(7), 1754-1760.
Philip, K., Mills, T. W., Davies, J., Chen, N. Y., Karmouty-Quintana, H., Luo, F., ... & Eltzschig, H. K. (2017). HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis. The FASEB Journal, fj-201700219R.
2016
Jiang, X., Zha, B., Liu, X., Liu, R., Liu, J., Huang, E., ... & Wang, L. (2016). STAT6 deficiency ameliorates Graves' disease severity by suppressing thyroid epithelial cell hyperplasia. Cell death & disease, 7(12), e2506.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5260978/
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0157376
Quail, D. F., Bowman, R. L., Akkari, L., Quick, M. L., Schuhmacher, A. J., Huse, J. T., ... & Joyce, J. A. (2016). The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science, 352(6288), aad3018.
http://science.sciencemag.org/content/352/6288/aad3018.full
Higuchi, H., Shoji, T., Murase, Y., Iijima, S., & Nishijima, K. I. (2016). Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264. Bioscience, biotechnology, and biochemistry, 80(3), 501-509.
Saito, Y., Azuma, A., Matsuda, K., Kamio, K., Abe, S., & Gemma, A. (2016). Pirfenidone exerts a suppressive effect on CCL18 expression in U937-derived macrophages partly by inhibiting STAT6 phosphorylation. Immunopharmacology and immunotoxicology, 38(6), 464-471.
Quail, D. F., Bowman, R. L., Akkari, L., Quick, M. L., Schuhmacher, A. J., Huse, J. T., ... & Joyce, J. A. (2016). The tumor microenvironment underlies acquired resistance to CSF-1R inhibition in gliomas. Science, 352(6288), aad3018.
http://science.sciencemag.org/content/352/6288/aad3018
Hosokawa, Y., Hosokawa,I., Shindo, S., Ozaki, K., & Matsuo, T. (2016). IL-4 ModulatesCCL11 andCCL20 Productions from IL-1β-Stimulated Human Periodontal Ligament Cells. Cellular Physiology and Biochemistry, 38(1), 153-159.
http://www.karger.com/Article/Abstract/438617
Jeong, J., Kim, Y. J., Yoon, S. Y., Kim, Y. J., Kim, J. H., Sohn, K. Y., ... & Kim, J. W. (2016). PLAG (1-Palmitoyl-2-Linoleoyl-3-Acetyl-rac-Glycerol) modulates eosinophil chemotaxis by regulatingCCL26 expression from epithelial cells. PloS one, 11(3), e0151758.
http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0151758
Han, Y. H., Chong, S., Sohn, K. Y., Kim, M. H., & Kim, J. W. (2016). "METHODS FOR TREATING LEUKOPENIA AND THROMBOCYTOPENIA." U.S.Patent No. 20,160,128,966.Washington,DC:U.S.Patent and Trademark Office.
http://www.freepatentsonline.com/y2016/0128966.html
Aguilar-Hernandez, M. M., Blunt, M. D., Dobson, R., Yeomans, A., Thirdborough, S., Larrayoz, M., ... & Johnson, P. M. (2016). IL-4 enhances expression and function of surface IgM inCLLcells. Blood, blood-2015.
http://www.bloodjournal.org/content/early/2016/03/21/blood-2015-11-682906.abstract
2015
Kouchi, Z. (2015). Monoacylglycerol lipase promotes Fcγ receptor-mediated phagocytosis in microglia but does not regulate LPS-induced upregulation of inflammatory cytokines. Biochemical and biophysical research communications, 464(2), 603-610.
http://www.sciencedirect.com/science/article/pii/S0006291X15302503
*AS1517499 and 10058-F4 from Axon Medchem
Kiguchi, N., Kobayashi, Y., Saika, F., Sakaguchi, H., Maeda, T., & Kishioka, S. (2015). Peripheral interleukin-4 ameliorates inflammatory macrophage-dependent neuropathic pain. Pain, 156(4), 684-693.
http://journals.lww.com/pain/Abstract/2015/04000/Peripheral_interleukin_4_ameliorates_inflammatory.15.aspx
Yoon, S. Y., Kang, H. B., Ko, Y. E., Shin, S. H., Kim, Y. J., Sohn, K. Y., ... & Kim, J. W. (2015). 1-palmitoyl-2-linoleoyl-3-acetyl-rac-glycerol (EC-18) Modulates Th2 Immunity through Attenuation of IL-4 Expression. Immune network, 15(2), 100-109.
http://synapse.koreamed.org/search.php?where=aview&id=10.4110/in.2015.15.2.100&code=0078IN&vmode=FULL
Villa, A., Rizzi, N., Vegeto, E., Ciana, P., & Maggi, A. (2015). Estrogen accelerates the resolution of inflammation in macrophagic cells. Scientific reports, 5.
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4609992/
Geskin, L. J., Viragova, S., Stolz, D. B., & Fuschiotti, P. (2015). Interleukin-13 is overexpressed in cutaneous T-cell lymphoma cells and regulates their proliferation. Blood, 125(18), 2798-2805.
http://www.bloodjournal.org/content/125/18/2798.abstract
Kumar, R., Mickael, C., Chabon, J., Gebreab, L., Rutebemberwa, A., Garcia, A. R., ... & Barthel, L. (2015). The causal role of IL-4 and IL-13 in Schistosoma mansoni pulmonary hypertension. American journal of respiratory and critical care medicine, 192(8), 998-1008.
https://scholar.google.nl/scholar?q=as1517499+axon+medchem&hl=en&as_sdt=0%2C5&as_ylo=2015&as_yhi=2015#
Higuchi, H., Shoji, T., Murase, Y., Iijima, S., & Nishijima, K. I. (2015). Siglec-9 modulated IL-4 responses in the macrophage cell line RAW264. Bioscience, biotechnology, and biochemistry, 1-9.
http://www.tandfonline.com/doi/abs/10.1080/09168451.2015.1104238
Dames, P., Bergann, T., Fromm, A., Bücker, R., Barmeyer, C., Krug, S. M., ... & Schulzke, J. D. (2015). Interleukin‐13 affects the epithelial sodium channel in the intestine by coordinated modulation ofSTAT6 and p38 MAPK activity. The Journal of Physiology, 593(24), 5269-5282.
http://onlinelibrary.wiley.com/doi/10.1113/JP271156/full
Su, S., Zhao, Q., He, C., Huang, D., Liu, J., Chen, F., ... &Yao, H. (2015). miR-142-5p and miR-130a-3p are regulated by IL-4 and IL-13 and control profibrogenic macrophage program. Nature communications, 6.
http://www.nature.com/ncomms/2015/151005/ncomms9523/full/ncomms9523.html
2014
Volpe, E., Pattarini, L., Martinez-Cingolani, C., Meller, S., Donnadieu, M. H., Bogiatzi, S.I., ... & Paronetto, M. P. (2014). Thymic stromal lymphopoietin links keratinocytes and dendritic cell–derived IL-23 in patients with psoriasis. Journal of Allergy and Clinical Immunology, 134(2), 373-381.
http://www.sciencedirect.com/science/article/pii/S0091674914005971
Ferreira, R., Lively, S., & Schlichter, L. C. (2014). IL-4 type 1 receptor signaling up-regulates KCNN4 expression, and increases the KCa3. 1 current and its contribution to migration of alternative-activated microglia. Front Cell Neurosci, 8(183.10), 3389.
http://file2.selleck.jp/citations/tofacitinib-Fedratinib-Front-Cell-Neurosci-20140822.pdf
Hui, C. C. K., Murphy, D. M., Neighbour, H., Al‐Sayegh, M., O'Byrne, S., Thong, B., ... & Larché, M. (2014). T cell‐mediated induction of thymic stromal lymphopoietin in differentiated human primary bronchial epithelial cells. Clinical & Experimental Allergy, 44(7), 953-964.
http://onlinelibrary.wiley.com/doi/10.1111/cea.12330/full
Roh, K. B., Kim,I.H., Kim, Y. S., Lee, M., Lee, J. A., Jung, E., & Park, D. (2014). Synephrine inhibits eotaxin-1 expression via theSTAT6 signaling pathway. Molecules, 19(8), 11883-11895.
http://www.mdpi.com/1420-3049/19/8/11883/htm
John, L. (2014). Mechanismen der Transzytose von Makromolekülen bei Morbus Crohn: Untersuchungen am Zellmodell T84 und an humanen Kolon-Biopsien (Doctoral dissertation, Freie UniversitätBerlin).
http://www.diss.fu-berlin.de/diss/receive/FUDISS_thesis_000000097497?lang=de