Yilmaz, A., Gurhan, G., Comar, M. Y., Viukov, S., Serfaty, I., Gayretli, M., ... & Hanna, J. H. (2025). Transgene-free generation of mouse post-gastrulation whole embryo models solely from naive ESCs and iPSCs. Cell Stem Cell, 32(10), 1545-1562.

* CHIR99021 + PD0325901 + Y27632 + RepSox, AM580, XAV939, TRULI, etc from Axon Medchem

 

Rossignoli, G., Oberhuemer, M., Brun, I. S., Zorzan, I., Osnato, A., Wenzel, A., ... & Martello, G. (2025). Feeder-free culture of naive human pluripotent stem cells retaining embryonic, extraembryonic and blastoid generation potential. bioRxiv, 2025-01.

* PD0325901, XAV939, GO6983, Y27632, CHIR99021, A83-01, SB431542, PD173174, ec from Axon Medchem

 

Arboit, M., Zorzan, I., Pensabene, E., Pellegrini, M., Bertelli, F., Panebianco, G., ... & Martello, G. (2025). KLF7 is a general inducer of human pluripotency. EMBO reports, 26(22), 5372.

* PD0325901, CHIR99021, XAV939, GO6983, Y27632, CHIR99021, A83-01, SB432542, etc from Axon Medchem

 

Van Nerum, K., Wenzel, A., Argemi-Muntadas, L., Kafkia, E., Drews, A., Brun, I. S., ... & Żylicz, J. J. (2025). α-Ketoglutarate promotes trophectoderm induction and maturation from naive human embryonic stem cells. Nature Cell Biology, 27(5), 749-761.

* PD0325901, CHIR99021, GO6983, XAV939, SB431542, Y27632, A83-01, Valproic acid from Axon Medchem

 

Onfray, C., Chevolleau, S., Moinard, E., Girard, O., Mahadik, K., Allsop, R., ... & David, L. (2024). Unraveling hallmark suitability for staging pre-and post-implantation stem cell models. Cell Reports, 43(5).

*Y-27632, CHIR99021, PD0325901, SB431542, A83-01, GO6983, XAV939, IWR-endo-1 from Axon Medchem

 

Laterza, C., Cesare, E., Stuart, H. T., D’Ercole, M., Gesualdo, A., La Barbera, M. G., ... & Elvassore, N. (2024). From naïve pluripotency to human neural organoids through a three-dimensional morphogenetic continuum. bioRxiv, 2024-11.

* SB431542 and XAV939 from Axon Medchem

 

Żylicz, J., van Nerum, K., Wenzel, A., Muntadas, L. A., Kafkia, E., Lavro, V., ... & Moritz, T. (2024). Metabolic rewiring underpins human trophoblast induction. Preprint at https://doi. org/10.21203/rs, 3.

* CHIR99021, PD0325901, Y27632, GO6983, XAV939,

 

Arboit, M., Zorzan, I., Pellegrini, M., Martini, P., Carbognin, E., & Martello, G. (2023). KLF7 is a general inducer of human pluripotency. bioRxiv, 2023-09.

*7i: PD0325901, Y27632, XAV939, GO6983, CHIR99021, A83-01, SB432541 from Axon Medchem

 

Carbognin, E., Carlini, V., Panariello, F., Chieregato, M., Guerzoni, E., Benvegnù, D., ... & Martello, G. (2023). Esrrb guides naive pluripotent cells through the formative transcriptional programme. Nature cell biology, 25(5), 643-657.

*4i from Axon MedChem, including PD0325901, CHIR99021, XAV939 and Y27632.

 

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Corridori, C., ... & Martello, G. (2023). Chemical conversion of human conventional PSCs to TSCs following transient naive gene activation. EMBO reports, 24(4), e55235.

* PD0325901, XAV939, GO6983, Y27632, CHIR99021, A83-01 and SB431542 from Axon Medchem

 

Zorzan, I., Betto, R. M., Rossignoli, G., Arboit, M., Drusin, A., Martini, P., & Martello, G. (2022). Chemical conversion of human conventional Pluripotent Stem Cells to Trophoblast Stem Cells. bioRxiv, 2022-04.

*PD0325901, XAV939, Go6983, Y27632, CHIR99021, A83-01, SB431542 from Axon Medchem

 

Viukov, S., Shani, T., Bayerl, J., Sheban, D., Stelzer, Y., Novershtern, N., & Hanna, J. H. (2022). Human primed and naïve PSCs are both competent in differentiating into bona fide trophoblast stem cells. BioRxiv, 2022-05.

*PD0325901, XAV939, GO6983, CGP77675, BIRB796, A883-01, CHIR99021, Y27632 from Axon Medchem

 

Girard, O., Lavigne, R., Chevolleau, S., Onfray, C., Com, E., Schmit, P. O., ... & Pineau, C. (2022). Naive Pluripotent and Trophoblastic Stem Cell Lines as a Model for Detecting Missing Proteins in the Context of the Chromosome-Centric Human Proteome Project. Journal of proteome research.

* PD0325901, XAV939, GO6983, Y27632 and CHIR99021 from Axon Medchem

 

Viukov, S., Shani, T., Bayerl, J., Aguilera-Castrejon, A., Oldak, B., Sheban, D., ... & Novershtern, N. (2022). Human primed and naïve PSCs are both able to differentiate into trophoblast stem cells. Stem cell reports, 17(11), 2484-2500.

* PD0325901, XAV939, Go6983, Y27632, CGP77675, PD173074 and CHIR99021 from Axon Medchem

 

Bayerl, J., Ayyash, M., Shani, T., Manor, Y. S., Gafni, O., Massarwa, R., ... & Hanna, J. H. (2021). Principles of signaling pathway modulation for enhancing human naive pluripotency induction. Cell Stem Cell. 28(9), 1549-1565.

* Y27632 and 14 other inhibitors from Axon Medchem, including CHIR99021, PD0325901, IWR1, BIRB0796, Go6983, CGP77675, RIN1, LDN193189, A8301, SB590885, BIX02189, RU-SKI43, BIX02194, XAV939

 

Bayerl, J., Ayyash, M., Shani, T., Manor, Y., Gafni, O., Kalma, Y., ... & Hanna, J. H. (2020). Tripartite Inhibition of SRC-WNT-PKC Signalling Consolidates Human Naïve Pluripotency. bioRxiv.

* CHIR99021, PD0325901, IWR-1, XAV939, BIRB0796, Go6983, Y27632, CGP77675, LDN193189, A83-01, DBZ, SB590885, BIX02189, RU-SKI43, BIX-02194 etc. from Axon Medchem

 

Kugler, J. (2017). Essential Signaling Cascades as Predictive Endpoints for Teratogenicity in vitro: A Proof of Principle Study (Doctoral dissertation).

 

Kugler, Josephine, et al. "Identification and characterization of teratogenic chemicals using embryonic stem cells isolated from a Wnt/β-Catenin-reporter transgenic mouse line." Toxicological Sciences (2016): kfw094.

*CHIR99021 and XAV939 from Axon Medchem