List of publications using LY 2157299 (Axon 1491) purchased from Axon Medchem
(Total 49 publications; updated up to December 2025)
2025
Pamplona, C. C., Bergada, C. B., Jaynes, C. L., Hamelink, T. L., Lantinga, V. A., Ogurlu, B., ... & van Leeuwen, L. L. (2025). Exploring ex vivo modulation of fibrosis in discarded human donor kidneys. bioRxiv, 2025-07.
Amabile, G., D’Addio, F., Maestroni, A., Zangarini, M., Porzio, S., Camboni, M. G., ... & Fiorina, P. (2025). Targeting of the IGFBP3/TMEM219 pathway restores intestinal stem cells capability of healing mucosa in gastrointestinal autoimmune disorders. Pharmacological Research, 107901.
Hörner, M., Burkard, N., Kelm, M., Leist, A., Selig, T., Kollmann, C., ... & Schlegel, N. (2025). Glial cell line derived neurotrophic factor (GDNF) induces mucosal healing via intestinal stem cell niche activation. Cell Proliferation, 58(2), e13758.
Gudiño, V., Cho, J. W., Caballol, B., Corraliza, A. M., Veny, M., Dotti, I., ... & Salas, A. (2025). TL1A-activated T cells remodel the rectal mucosa in Crohn’s disease patients with perianal fistulizing disease. bioRxiv, 2025-06.
2024
Bustamante-Madrid, P., Barbáchano, A., Albandea-Rodríguez, D., Rodríguez-Cobos, J., Rodríguez-Salas, N., Prieto, I., ... & Fernández-Barral, A. (2024). Vitamin D opposes multilineage cell differentiation induced by Notch inhibition and BMP4 pathway activation in human colon organoids. Cell Death & Disease, 15(4), 301.
Delle Cave, D., Mangini, M., Tramontano, C., De Stefano, L., Corona, M., Rea, I., ... & Lonardo, E. (2024). Hybrid biosilica nanoparticles for in-vivo targeted inhibition of colorectal cancer growth and label-free imaging. International Journal of Nanomedicine, 12079-12098.
2023
Nagler, S., Ghoreishi, Y., Kollmann, C., Kelm, M., Gerull, B., Waschke, J., ... & Schlegel, N. (2023). Plakophilin 2 regulates intestinal barrier function by modulating protein kinase C activity in vitro. Tissue Barriers, 11(4), 2138061.
Kollmann, C., Buerkert, H., Meir, M., Richter, K., Kretzschmar, K., Flemming, S., ... & Schlegel, N. (2023). Human organoids are superior to cell culture models for intestinal barrier research. Frontiers in Cell and Developmental Biology, 11, 1223032.
Montero, J. C., Del Carmen, S., Abad, M., Sayagués, J. M., Barbáchano, A., Fernández-Barral, A., ... & Pandiella, A. (2023). An amino acid transporter subunit as an antibody–drug conjugate target in colorectal cancer. Journal of Experimental & Clinical Cancer Research, 42(1), 200.
2022
Dotti, I., Mayorgas, A., & Salas, A. (2022). Generation of human colon organoids from healthy and inflammatory bowel disease mucosa V.(cfh7tj9n).
van Leeuwen, L. L., Leuvenink, H. G., Kessler, B. M., Olinga, P., & Ruigrok, M. J. (2022). Targeted delivery of galunisertib attenuates fibrogenesis in an integrated ex vivo renal transplant and fibrosis model. bioRxiv, 2022-03.
Ferreira, E., Voermans, C., van de Peppel, J., Ghebes, C. A., Morhayim, J., Kleijer, M., ... & Stromal, F. B. M. M. (2022). Corina A. Ghebes1, Jess Morhayim2, Marion Kleijer1, Merve Koroglu1, Stefan J. Erkeland3, Remco Hoogenboezem2, Eric Bindels2, Floris PJ van Alphen4, Maartje van den Biggelaar4, Martijn A. Nolte1, 4, Bram CJ van der Eerden5, Eric Braakman2, Carlijn Voermans1*† and Jeroen van de Peppel5. MSC-derived Extracellular Vesicles and Secreted Factors as ‘Cell-Free'Therapeutic Alternatives in Regenerative Medicine, 694908037.
Madrid, P. D. L. P. B. (2022). Establecimiento de un sistema de diferenciación celular en organoides colónicos humanos. Efecto de la vitamina D (Doctoral dissertation, Universidad Autónoma de Madrid).
2021
Solà Tapias, N., Denadai-Souza, A., Rolland-Fourcade, C., Quaranta-Nicaise, M., Blanpied, C., Marcellin, M., ... & Barreau, F. (2021). Colitis linked to endoplasmic reticulum stress induces trypsin activity affecting epithelial functions. Journal of Crohn's and Colitis, 15(9), 1528-1541.
* GB83 and LY2157299 from Axon Medchem
Tapias, N. S., Denadai-Souza, A., Rolland-Fourcade, C., Quaranta-Nicaise, M., Blanpied, C., Marcellin, M., ... & Bonnart, C. INSERM UMR-1220 Purpan Hospital, CS60039, 31024 Toulouse cedex 03 France Phone:+ 33 5 62 74 45 00; Fax:+ 33 5 62 74 45 58 e-mail: nathalie. vergnolle@ inserm. fr.
* GB83 and LY2157299 from Axon Medchem
Ghebes, C. A., Morhayim, J., Kleijer, M., Koroglu, M., Erkeland, S. J., Hoogenboezem, R., ... & van de Peppel, J. (2021). Extracellular vesicles derived from adult and fetal bone marrow mesenchymal stromal cells differentially promote ex vivo expansion of hematopoietic stem and progenitor cells. Frontiers in Bioengineering and Biotechnology, 9, 640419.
Meir, M., Kannapin, F., Diefenbacher, M., Ghoreishi, Y., Kollmann, C., Flemming, S., ... & Schlegel, N. (2021). Intestinal epithelial barrier maturation by enteric glial cells is GDNF-dependent. International journal of molecular sciences, 22(4), 1887.
Zhang, Y. L., Zhang, Y. Q., Lin, H. L., Qin, Y. J., Zeng, J., Chen, Y. L., ... & Zhang, H. Y. (2021). Epigallocatechin-3-gallate increases autophagic activity attenuating TGF-β1-induced transformation of human Tenon's fibroblasts. Experimental Eye Research, 204, 108447.
Managò, S., Tramontano, C., Delle Cave, D., Chianese, G., Zito, G., De Stefano, L., ... & Rea, I. (2021). SERS quantification of galunisertib delivery in colorectal cancer cells by plasmonic‐assisted diatomite nanoparticles. Small, 17(34), 2101711.
Tramontano, C., Miranda, B., Chianese, G., De Stefano, L., Forestiere, C., Pirozzi, M., & Rea, I. (2021). Design of gelatin-capped plasmonic-diatomite nanoparticles with enhanced galunisertib loading capacity for drug delivery applications. International Journal of Molecular Sciences, 22(19), 10755.
2020
Ferrer-Picón, E., Dotti, I., Corraliza, A. M., Mayorgas, A., Esteller, M., Perales, J. C., ... & Salas, A. (2020). Intestinal inflammation modulates the epithelial response to butyrate in patients with inflammatory bowel disease. Inflammatory bowel diseases, 26(1), 43-55.
Fernández‐Barral, A., Costales‐Carrera, A., Buira, S. P., Jung, P., Ferrer‐Mayorga, G., Larriba, M. J., ... & Barbáchano, A. (2020). Vitamin D differentially regulates colon stem cells in patient‐derived normal and tumor organoids. The FEBS journal, 287(1), 53-72.
2019
Costales-Carrera, A., Fernández-Barral, A., Bustamante-Madrid, P., Guerra, L., Cantero, R., Barbáchano, A., & Muñoz, A. (2019). Plocabulin displays strong cytotoxic activity in a personalized colon cancer patient-derived 3D organoid assay. Marine drugs, 17(11), 648.
Maestroni, A. M. (2019). Dysregulation of Intestinal stem cells in Crohn's disease.
Meir, M., Burkard, N., Ungewiß, H., Diefenbacher, M., Flemming, S., Kannapin, F., ... & Schlegel, N. (2019). Neurotrophic factor GDNF regulates intestinal barrier function in inflammatory bowel disease. The Journal of clinical investigation, 129(7), 2824-2840.
2018
Sébert, M., Denadai‐Souza, A., Quaranta, M., Racaud‐Sultan, C., Chabot, S., Lluel, P., ... & Vergnolle, N. (2018). Thrombin modifies growth, proliferation and apoptosis of human colon organoids: a protease‐activated receptor 1‐and protease‐activated receptor 4‐dependent mechanism. British Journal of Pharmacology, 175(18), 3656-3668.
Bassolas Molina, H. (2018). Resposta T específica contra antígens de la microbiota comensal en la malaltia de Crohn i inhibició de RORγt com a estratègia terapèutica.
2017
Kawai, T., Yasuchika, K., Ishii, T., Katayama, H., Yoshitoshi, E. Y., Ogiso, S., ... & Uemoto, S. (2017). Identification of keratin 19-positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21-1. Cancer Medicine, 6(11), 2531-2540.
Kawai, T., Yasuchika, K., Seo, S., Higashi, T., Ishii, T., Miyauchi, Y., ... & Uemoto, S. (2017). Identification of keratin 19–positive cancer stem cells associating human hepatocellular carcinoma using 18F-Fluorodeoxyglucose positron emission tomography. Clinical Cancer Research, 23(6), 1450-1460.
Jeibmann, A., Schulz, J., Eikmeier, K., Johann, P. D., Thiel, K., Tegeder, I., ... & Paulus, W. (2017). SMAD dependent signaling plays a detrimental role in a fly model of SMARCB1-deficiency and the biology of atypical teratoid/rhabdoid tumors. Journal of neuro-oncology, 131(3), 477-484.
2016
Schweinlin, M., Wilhelm, S., Schwedhelm, I., Hansmann, J., Rietscher, R., Jurowich, C., ... & Metzger, M. (2016). Development of an advanced primary human in vitro model of the small intestine. Tissue Engineering Part C: Methods, 22(9), 873-883.
Montorsi, L., Parenti, S., Losi, L., Ferrarini, F., Gemelli, C., Rossi, A., ... & Zanocco-Marani, T. (2016). Expression of μ-protocadherin is negatively regulated by the activation of the β-catenin signaling pathway in normal and cancer colorectal enterocytes. Cell death & disease, 7(6), e2263.
Kawai, T., Yasuchika, K., Seo, S., Higashi, T., Ishii, T., Miyauchi, Y., ... & Ogiso, S. (2016). Identification of keratin19-positive cancer stem cells associating human hepatocellular carcinoma using 18F-fluorodeoxyglucose positron emission tomography. Clinical Cancer Research, clincanres-0871.
Calderón-Gómez, E., Bassolas-Molina, H., Mora-Buch, R., Dotti, I., Planell, N., Esteller, M., ... & Ordás, I. (2016). Commensal-specific CD4+ cells from patients with Crohn’s disease have a T-helper 17 inflammatory profile. Gastroenterology, 151(3), 489-500.
Schweinlin, M. O. (2016). Development of advanced human intestinal in vitro models.
2015
Lin, C., Rezaee, F., Waasdorp, M., Shi, K., van der Poll, T., Borensztajn, K., & Spek, C. A. (2015). Protease activated receptor-1 regulates macrophage-mediated cellular senescence: a risk for idiopathic pulmonary fibrosis. Oncotarget, 6(34), 35304.
(SB431542 and LY2157299 from Axon Medchem)
Adkins, C. E., Nounou, M. I., Mittapalli, R. K., Terrell-Hall, T. B., Mohammad, A. S., Jagannathan, R., & Lockman, P. R. (2015). A novel preclinical method to quantitatively evaluate early-stage metastatic events at the murine blood–brain barrier. Cancer Prevention Research, 8(1), 68-76.
Keratin 19, a cancer stem cell marker in human hepatocellular carcinoma.
Kawai, T., Yasuchika, K., Ishii, T., Katayama, H., Yoshitoshi, E. Y., Ogiso, S., ... & Uemoto, S. (2015).
Clin Cancer Res. 2015 Mar 27. [Epub ahead of print]
A Novel Preclinical Method to Quantitatively Evaluate Early-Stage Metastatic Events at the Murine Blood–Brain Barrier.
Adkins, C. E., Nounou, M. I., Mittapalli, R. K., Terrell-Hall, T. B., Mohammad, A. S., Jagannathan, R., & Lockman, P. R. (2015).
Cancer Prev Res (Phila). 2015 Jan;8(1):68-76.
COMPOSITIONS AND METHODS FOR TREATING OR PREVENTING OSTEOARTHRITIS.
Cao, Xu.
U.S. Patent No. 20,150,139,909. 21 May 2015.
2014
Benzalkonium Chloride Induces Subconjunctival Fibrosis Through the COX-2–Modulated Activation of a TGF-β1/Smad3 Signaling Pathway.
Huang, C., Wang, H., Pan, J., Zhou, D., Chen, W., Li, W., ... & Liu, Z. (2014).
Invest Ophthalmol Vis Sci. 2014 Nov 18;55(12):8111-22.
Protease‐activated receptor 2 suppresses lymphangiogenesis and subsequent lymph node metastasis in a murine pancreatic cancer model.
Shi, K., Queiroz, K., Roelofs, J. J., van Noesel, C. J., Richel, D. J., & Spek, C. A. (2014).
J Pathol. 2014 Nov;234(3):398-409.
Targeted Therapy Sensitivity and Resistance in Solid Malignancies.
Jokinen, E. (2014).
PhD thesis. University of Oulu.
*LY2157299, SD208, XAV939 and DBZ from Axon Medchem have been used in this study.
2013
Programmed cell senescence during mammalian embryonic development.
Muñoz-Espín, D., Cañamero, M., Maraver, A., Gómez-López, G., Contreras, J., Murillo-Cuesta, S., ... & Serrano, M. (2013).
Cell. 2013 Nov 21;155(5):1104-18.
*LY2157299 from Axon Medchem has been used in this study.
Glucocorticoids alleviate intestinal ER stress by enhancing protein folding and degradation of misfolded proteins.
Das, I., Png, C. W., Oancea, I., Hasnain, S. Z., Lourie, R., Proctor, M., ... & McGuckin, M. A. (2013).
J Exp Med. 2013 Jun 3;210(6):1201-16.
2012 and earlier
Costimulatory protein 4IgB7H3 drives the malignant phenotype of glioblastoma by mediating immune escape and invasiveness.
Lemke, D., Pfenning, P. N., Sahm, F., Klein, A. C., Kempf, T., Warnken, U., ... & Wick, W. (2012).
Clinical Cancer Research, 18(1), 105-117.
Costimulatory protein 4IgB7H3 drives the malignant phenotype of glioblastoma by mediating immune escape and invasiveness.
Lemke, D., Pfenning, P. N., Sahm, F., Klein, A. C., Kempf, T., Warnken, U., ... & Wick, W. (2012).
Clin Cancer Res. 2012 Jan 1;18(1):105-17.
Cardiac treatment using anti-fibrotic agents.
Dudley, S. C., & Sutliff, R. L. (2011).
U.S. Patent Application 13/091,972. US 20110262398 A1.
Nodal/Activin signaling drives self-renewal and tumorigenicity of pancreatic cancer stem cells and provides a target for combined drug therapy.
Lonardo, E., Hermann, P. C., Mueller, M. T., Huber, S., Balic, A., Miranda-Lorenzo, I., ... & Heeschen, C. (2011).
Cell Stem Cell, 9(5), 433-446.
(This is an incomplete list, updated in AUGUST-2017)
