List of publications using BX 795 (Axon 1390) purchased from Axon Medchem 

(Total 28 publication citations updated until May 2019)

Matsumoto, G., Inobe, T., Amano, T., Murai, K., Nukina, N., & Mori, N. (2018). N-Acyldopamine induces aggresome formation without proteasome inhibition and enhances protein aggregation via p62/SQSTM1 expression. Scientific reports, 8(1), 9585.
https://www.nature.com/articles/s41598-018-27872-6

Li, Y., Østerhus, S., & Johnsen, I. B. (2018). human Metapneumovirus infection inhibits cathelicidin antimicrobial Peptide expression in human Macrophages. Frontiers in immunology, 9.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5946005/

Lee, S., Jeon, Y. M., Kim, S., Kwon, Y., Jo, M., Jang, Y. N., ... & Lee, S. B. (2018). PTK2 regulates the UPS impairment via p62 phosphorylation in TDP-43 proteinopathy. bioRxiv, 355446.
https://www.biorxiv.org/content/10.1101/355446v1.abstract

LEE, Mark Nackyoung; HACOHEN, Nir. Methods relating to DNA-sensing pathway related conditions. U.S. Patent No 9,814,741, 2017.
https://patents.google.com/patent/US9814741B2/en

Pillai, Smitha, et al. "Tank binding kinase 1 is a centrosome-associated kinase necessary for microtubule dynamics and mitosis." Nature communications 6 (2015).
http://www.nature.com/ncomms/2015/151210/ncomms10072/full/ncomms10072.html 

Keifer, Joyce, and Zhaoqing Zheng. "Coincidence detection in a neural correlate of classical conditioning is initiated by bidirectional 3‐phosphoinositide‐dependent kinase‐1 signalling and modulated by adenosine receptors." The Journal of physiology 593.7 (2015): 1581-1595.
*BX912 and BX795 were purchased from Axon Medchem.
 
Awuh, Jane Atesoh, et al. "Keap1 regulates inflammatory signaling in Mycobacterium avium-infected human macrophages." Proceedings of the National Academy of Sciences 112.31 (2015): E4272-E4280.
 
di Blasio, Laura, et al. "PDK1 regulates focal adhesion disassembly by modulating endocytosis of αvβ3 integrin." Journal of cell science 128.5 (2015): 863-877.
 
di Blasio, Laura, et al. "PDK1 regulates focal adhesion disassembly through modulation of αvβ3 integrin endocytosis." J Cell Sci (2015): jcs-149294.
 
Chau, Tieu-Lan, et al. "A Role for APPL1 in TLR3/4-Dependent TBK1 and IKKε Activation in Macrophages." The Journal of Immunology 194.8 (2015): 3970-3983.
* BX795, U0126, and GSK1120212 inhibitors were from Axon Medchem.
 
Dieterle, Alexandra Maria, et al. "PDK1 controls upstream PI3K expression and PIP3 generation." Oncogene 33.23 (2014): 3043-3053.
 
Parsons, K. S., A. C. Hsu, and P. A. B. Wark. "TLR3 and MDA5 signalling, although not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection." Clinical & Experimental Allergy 44.1 (2014): 91-101.
 
Deng, Tao, et al. "shRNA kinome screen identifies TBK1 as a therapeutic target for HER2+ breast cancer." Cancer research 74.7 (2014): 2119-2130.
 
Shanmugasundaram, Karthigayan, et al. "The oncometabolite fumarate promotes pseudohypoxia through noncanonical activation of NF-κB signaling." Journal of Biological Chemistry 289.35 (2014): 24691-24699.
 
Lee, Mark Nackyoung, and Nir Hacohen. "Methods relating to dna-sensing pathway related conditions." U.S. Patent Application No. 14/676,933.
 
Rajasekaran, Vidya. Tissue Transglutaminase (TG2) is a potential therapeutic target in the treatment of chemoresistant breast cancer. Diss. Aston University, 2014.
 
METHODS AND COMPOSITIONS FOR TREATING CANCER.
Q Yu, J Tan - US Patent 20,130,123,328, 2013.
Read more: http://www.freepatentsonline.com/y2013/0123328.html 
 
Hyaluronan fragments induce IFNbeta via a novel TLR4-TRIF-TBK1-IRF3-dependent pathway. 
KE Black, SL Collins, RS Hagan, MJ Hamblin, Y Chan-Li, RW Hallowell, JD Powell & MR Horton. 
J. Inflam, 2013, 10(1), 23. doi:10.1186/1476-9255-10-23
Read more: http://www.journal-inflammation.com/content/10/1/23/abstract 
 
PDK1 Signaling Towards PLK1-Myc Activation Confers Oncogenic Transformation and Tumor Initiating Cell Activation and Resistance to mTOR-targeted Therapy.
J Tan, Z Li, PL Lee, P Guan, MY Aau, ST Lee, M Feng, CZ Lim, EYJ Lee, ZN Wee, YC Lim, RKM Karuturi and Q Yu.
Cancer Discovery, Published Online July 25, 2013.
Read more: http://www.ncbi.nlm.nih.gov/pubmed/23887393
... 60 inhibitors including BX795 were purchased from Axon Medchem
 
TLR3 and MDA5 signalling though not expression, is impaired in asthmatic epithelial cells in response to rhinovirus infection.
KS Parsons, AC Hsu, PAB Wark - Clin. & Exp. Allergy, 2013.  DOI: 10.1111/cea.12218.
Read more: http://onlinelibrary.wiley.com/doi/10.1111/cea.12218/abstract 
 
3-Phosphoinositide-Dependent Kinase 1 Controls Breast Tumor Growth in a Kinase-Dependent but Akt-Independent Manner1,2.
PA Gagliardi, L di Blasio, F Orso, G Seano, R Sessa, D Taverna, F Bussolino, L Primo.
Neoplasia. 2012, 14 (8), 719–731.   PMCID: PMC3431179   
 
Phosphorylation of microtubule-associated protein tau by AMPK-related kinases.
H Yoshida, M Goedert.
J Neurochem. 2012, 120 (1), 165–176.    DOI: 10.1111/j.1471-4159.2011.07523.x 
 
Localization and retention of p90 ribosomal S6 kinase 1 in the nucleus: implications for its function.
X Gao, D Chaturvedi, TB Patel.
Mol. Biol. Cell, 2012, 23 (3), 503-515.  doi: 10.1091/mbc.E11-07-0658 
 
High-throughput RNAi screening reveals novel regulators of telomerase.
MA Cerone, DJ Burgess, C Naceur-Lombardelli, CJ Lord, A Ashworth.
Cancer Res. 2011, 71, 3328. doi: 10.1158/0008-5472.CAN-10-2734 
 
The Protein Kinase IKKε Is a Potential Target for the Treatment of Inflammatory Hyperalgesia.
CV Möser, K Kynast, K Baatz, OQ Russe, N Ferreirós, H Costiuk, R Lu, A Schmidtko, I Tegeder, G Geisslinger, E Niederberger.
J. Immunol. 2011, 187 (5), 2617-2625. doi: 10.4049/jimmunol.1004088   
 
PKC‐dependent endocytosis of the Helicobacter pylori vacuolating cytotoxin in primary T lymphocytes.
X Sewald, L Jiménez‐Soto, R Haas.
Cellular Microbiol. 2011, 13 (3), 482–496.  DOI: 10.1111/j.1462-5822.2010.01551.x 
 
Specification of the NF-κB transcriptional response by p65 phosphorylation and TNF-induced nuclear translocation of IKKε.
R Moreno, JM Sobotzik, C Schultz, M. Lienhard Schmitz.
Nucl. Acids Res. 2010, 38 (18), 6029-6044. doi: 10.1093/nar/gkq439
 
Nature and Duration of Growth Factor Signaling through Receptor Tyrosine Kinases Regulates HSV-1 Latency in Neurons.
V Camarena, M Kobayashi, JY Kim, P Roehm, R Perez, J Gardner, AC Wilson, I Mohr, MV Chao.
Cell Host & Microbe. 2010, 8 (4), 320-330.
http://www.sciencedirect.com/science/article/pii/S1931312810003094 
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