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PFI-6

Axon 4474
CAS:  2675452-91-0
  • Optical Purity:  98% e.e.
  • Soluble in DMSO
  • MF:  C22H21N3O4
  • MW:  391.42

Description

PFI-6 is a selective chemical probe for the YEATS domains of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with IC50 values of 140 nM and 160 nM for MLLT1 and MLLT3, respectively. PFI-6 selectively targets YEATS domain-mediated recognition of acetylated and acylated lysine residues, providing a valuable tool for investigating chromatin-associated transcriptional regulation.

MLLT1 and MLLT3 are epigenetic reader proteins that recognize histone acylation marks through their YEATS domains and play important roles in chromatin organization, transcriptional control, and oncogenic gene regulation. PFI-6 enables selective interrogation of YEATS domain biology and epigenetic signaling pathways.

Key Features

  • Selective MLLT1 and MLLT3 YEATS domain probe
  • IC50: 140 nM for MLLT1 (ENL/YEATS1)
  • IC50: 160 nM for MLLT3 (AF9/YEATS3)
  • Targets epigenetic YEATS reader domains
  • Useful chemical probe for chromatin biology research

Applications

  • YEATS domain biology research
  • Epigenetics and chromatin regulation studies
  • Histone acetylation and acylation research
  • Transcriptional regulation investigations
  • Chemical biology and target validation studies

More Information

Parent CAS No. 2675452-91-0
Chemical Name N-((R)-1-Indanyl)-5-(3-hydroxy-4-(N,N-dimethylcarbamoyl)phenyl)-3-isoxazolecarboxamide
SMILES C1(C(N(C)C)=O)=C(O)C=C(C2=CC(C(=O)N[C@@H]3CCC4=CC=CC=C34)=NO2)C=C1 |&1:16,r|
InChi InChI=1/C22H21N3O4/c1-25(2)22(28)16-9-7-14(11-19(16)26)20-12-18(24-29-20)21(27)23-17-10-8-13-5-3-4-6-15(13)17/h3-7,9,11-12,17,26H,8,10H2,1-2H3,(H,23,27)/t17-/s3
InChiKey IXWUILRSNIQHDM-SCBJWRGWNA-N
CID 155925909
Short Description MLLT1/3 probe

Other Categories

More Categories

Axon Ligands™ for Cell Signaling & Oncology

Axon Ligand™ for Stem Cell Research 

Axon Ligands™ for Epigenetic Research 

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