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HypoxyStat
Axon 4416
Recently added
CAS:
2414508-40-8
- Optical Purity: 100% e.e.
- Soluble in DMSO
- MF: C21H21NO5
- MW: 367.40
Description
HypoxyStat is an orally active hypoxia mimetic which increases the binding affinity of hemoglobin for oxygen, thereby decreasing oxygen offloading to tissues. The increase of oxygen-hemoglobin affinity was shown to prevent and reverse pathology in a mouse model of mitochondrial disease. Also, HypoxyStat rescued hyperglycemia in mouse models of type 1 and type 2 diabetes.
More Information
| Parent CAS No. | 2414508-40-8 |
|---|---|
| Chemical Name | 2-(((S)-1-(2-Formylbenzoyl)-2-piperidyl)methoxy)-6-hydroxybenzaldehyde |
| SMILES | C1=CC(C(=O)N2CCCC[C@H]2COC2=C(C=O)C(O)=CC=C2)=C(C=O)C=C1 |&1:10,r| |
| InChi | InChI=1/C21H21NO5/c23-12-15-6-1-2-8-17(15)21(26)22-11-4-3-7-16(22)14-27-20-10-5-9-19(25)18(20)13-24/h1-2,5-6,8-10,12-13,16,25H,3-4,7,11,14H2/t16-/s3 |
| InChiKey | ZHAQYOLOVKUFPI-QEIABERDNA-N |
| CID | 146464568 |
| Short Description | Hypoxia mimetic |
References
- SY Blume et al. HypoxyStat, a small-molecule form of hypoxia therapy that increases oxygen-hemoglobin affinity. Cell. 2025 Mar 20;188(6):1580-1588.e11.
- Y Martí-Mateos et al. Red blood cells serve as a primary glucose sink to improve glucose tolerance at altitude. Cell Metab. 2026 Mar 3;38(3):529-545.e8.
