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UNC10142
Axon 4291
CAS:
N.A.
Purity:
99%
- Soluble in 0.1N HCl(aq), DMSO and EtOH
- MF: C33H52N6O3
- MW: 580.81
Description
UNC10142 is a first-in-class CHD1 tandem chromodomain antagonist with an IC50 value of 1.7 μM. Treatment of PTEN-deficient prostate cancer cells with UNC10142 produces a dose-dependent reduction in viability, while PTEN-intact prostate cancer cells are unaffected, phenocopying genetic loss of CHD1.
CHD1 is a chromodomain-helicase DNA-binding protein involved in chromatin regulation, transcriptional control, and histone-associated gene regulation. UNC10142 is a valuable chemical probe for studying CHD1 biology, chromodomain function, and PTEN-deficient prostate cancer models.
Key Features
- First-in-class CHD1 tandem chromodomain antagonist
- IC50: 1.7 μM
- Reduces viability of PTEN-deficient prostate cancer cells
- No effect on PTEN-intact prostate cancer cells
- Phenocopies genetic loss of CHD1
Applications
- CHD1 chromodomain research
- Chromatin regulation studies
- PTEN-deficient prostate cancer research
- Epigenetics and transcriptional regulation studies
- Chemical probe and target validation studies
More Information
| Parent CAS No. | N.A. |
|---|---|
| Chemical Name | 1-(4-((2-(1-Azonanyl)-6-methoxy-7-(3-piperidinopropoxy)-4-quinazolinyl)-N-methylamino)-1-piperidyl)-1-ethanone |
| MFCD | N.A. |
| Short Description | CHD1 antagonist |
UNC10142
UNC-10142
UNC 10142
CHD1 antagonist
CHD1 tandem chromodomain antagonist
CHD1
chromodomain antagonist
chromodomain-helicase DNA-binding protein
chromatin regulation
histone regulation
epigenetics
transcriptional regulation
PTEN-deficient prostate cancer
prostate cancer
chemical probe
CAS N.A.
Axon Medchem
Axon 4291
Histone
CHD
Proteins
Supplier
Vendor
