Pyridostatin hydrochloride
- RR82 hydrochloride
Axon 4076
- Parent CAS: 1085412-37-8
Purity:
95%
- Soluble in Water
- MF: C31H32N8O5
- MW: 778.94
Description
Pyridostatin stabilizes G-quadruplexes, targeting the proto-oncogene SRC and telomeric G-quadruplexes, inducing DNA damage and cell-cycle arrest, and is used for induced synthetic lethality in cancer cells.
More Information
| Parent CAS No. | 1085412-37-8 |
|---|---|
| Chemical Name | 4-(2-Aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide pentahydrochloride |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C(OCCN)=CC(C(=O)NC2C=C(OCCN)C3C=CC=CC=3N=2)=NC=1C(=O)NC1N=C2C=CC=CC2=C(OCCN)C=1.Cl.Cl.Cl.Cl.Cl |
| MFCD | N.A. |
| InChi | InChI=1S/C31H32N8O5.5ClH/c32-9-12-42-19-15-24(30(40)38-28-17-26(43-13-10-33)20-5-1-3-7-22(20)36-28)35-25(16-19)31(41)39-29-18-27(44-14-11-34)21-6-2-4-8-23(21)37-29;;;;;/h1-8,15-18H,9-14,32-34H2,(H,36,38,40)(H,37,39,41);5*1H |
| InChiKey | SRIZPFGTXSQRFM-UHFFFAOYSA-N |
| CID | 25227847 |
| Short Description | G-quadruplex DNA stabilizing agent |
References
- R Rodriguez et al. Small-molecule-induced DNA damage identifies alternative DNA structures in human genes. Nat Chem Biol. 2012 Feb 5;8(3):301-10.
- R Rodriguez et al. A novel small molecule that alters shelterin integrity and triggers a DNA-damage response at telomeres. J Am Chem Soc. 2008 Nov 26;130(47):15758-9.
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