TM30089 sodium
- CAY10471 sodium
Axon 3966
- Parent CAS: 844639-57-2
Purity:
99%
- Soluble in water and DMSO
- MF: C21H20FN2NaO4S
- MW: 438.45
Description
TM30089 is a selective CRTH2 antagonist, displaying high antagonistic potency on mouse CRTH2 with low affinity to TP and many other prostanoid receptors including the related anaphylatoxin C3a and C5a receptors.
More Information
| Parent CAS No. | 844639-57-2 |
|---|---|
| Chemical Name | Sodium 2-(3-(4-fluoro-N-methylphenylsulfonamido)-3,4-dihydro-1H-carbazol-9(2H)-yl)acetate |
| extra_info | Sold in collaboration with Chemietek |
| SMILES | C1C=C2C3CC(N(C)S(=O)(=O)C4C=CC(F)=CC=4)CCC=3N(CC(O[Na])=O)C2=CC=1 |
| MFCD | N.A. |
| InChi | InChI=1S/C21H21FN2O4S.Na/c1-23(29(27,28)16-9-6-14(22)7-10-16)15-8-11-20-18(12-15)17-4-2-3-5-19(17)24(20)13-21(25)26;/h2-7,9-10,15H,8,11-13H2,1H3,(H,25,26);/q;+1/p-1 |
| InChiKey | YPDAQXGTLKSFJN-UHFFFAOYSA-M |
| CID | 91885403 |
| Short Description | CRTH2 antagonist |
References
- L Uller et al. Antagonism of the prostaglandin D2 receptor CRTH2 attenuates asthma pathology in mouse eosinophilic airway inflammation. Respir Res. 2007 Feb 28;8(1):16.
- L Xue et al. Novel function of CRTH2 in preventing apoptosis of human Th2 cells through activation of the phosphatidylinositol 3-kinase pathway. J Immunol. 2009 Jun 15;182(12):7580-6.
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