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Lac-Phe
- N-lactoyl-phenylalanine - N-lactoyl-Phe
Axon 3776
CAS:
183241-73-8
- Optical Purity: Optically pure
- Soluble in water, DMSO and EtOH
- MF: C12H15NO4
- MW: 237.25
Description
Lac-Phe is an exercise-inducible metabolite that suppresses feeding and obesity.
More Information
| Parent CAS No. | 183241-73-8 |
|---|---|
| Chemical Name | (S)-2-((S)-2-Hydroxypropanamido)-3-phenylpropanoic acid |
| SMILES | [C@H](O)(C)C(N[C@@H](CC1C=CC=CC=1)C(O)=O)=O |&1:0,5,r| |
| MFCD | N.A. |
| InChi | InChI=1S/C12H15NO4/c1-8(14)11(15)13-10(12(16)17)7-9-5-3-2-4-6-9/h2-6,8,10,14H,7H2,1H3,(H,13,15)(H,16,17)/t8-,10-/m0/s1 |
| InChiKey | IIRJJZHHNGABMQ-WPRPVWTQSA-N |
| CID | 11075454 |
| Short Description | Metabolite |
References
- VL Li et al. An exercise-inducible metabolite that suppresses feeding and obesity. Nature. 2022 Jun;606(7915):785-790.
- RS Jansen et al. N-lactoyl-amino acids are ubiquitous metabolites that originate from CNDP2-mediated reverse proteolysis of lactate and amino acids. Proc Natl Acad Sci U S A. 2015 May 26;112(21):6601-6.
- S Xiao et al. Lac-Phe mediates the effects of metformin on food intake and body weight. Nat Metab. 2024 Mar 18.
- B Scott et al. Metformin and feeding increase levels of the appetite-suppressing metabolite Lac-Phe in humans. Nat Metab. 2024 Mar 18.
