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Apararenone
- MT3995
Axon 3742
CAS:
945966-46-1
Purity:
99%
- Soluble in DMSO
- MF: C17H17FN2O4S
- MW: 364.39
Description
Apararenone is a potent and highly selective nonsteroidal mineralocorticoid receptor (MR) antagonist (Ki value of 0.104 μM). Apararenone exhibited a more potent antihypertensive and organ-protective activity than steroidal MRA eplerenone in a primary aldosteronism rat model obtained by infusing aldosterone in uninephrectomized rats.
More Information
| Parent CAS No. | 945966-46-1 |
|---|---|
| Chemical Name | N-(4-(4-Fluorophenyl)-2,2-dimethyl-3-oxo-3,4-dihydro-2H-benzo[b][1,4]oxazin-7-yl)methanesulfonamide |
| SMILES | C1C=C2N(C3C=CC(F)=CC=3)C(=O)C(C)(C)OC2=CC=1NS(=O)(=O)C |
| MFCD | MFCD31657369 |
| InChi | InChI=1S/C17H17FN2O4S/c1-17(2)16(21)20(13-7-4-11(18)5-8-13)14-9-6-12(10-15(14)24-17)19-25(3,22)23/h4-10,19H,1-3H3 |
| InChiKey | AZNHWXAFPBYFGH-UHFFFAOYSA-N |
| CID | 24744336 |
| Short Description | MR antagonist |
