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Biliatresone

Axon 2867
CAS:  1801433-90-8
Purity:  98%
  • Soluble in DMSO
  • MF:  C18H16O6
  • MW:  328.32

Description

Biliatresone is a reactive natural biliary toxin that selectively injures extrahepatic cholangiocytes and produces biliary-atresia-like pathology in zebrafish and neonatal mouse models. Its electrophilic enone reacts with glutathione and other nucleophilic biomolecules.

Biliatresone depletes cellular glutathione, disrupts redox and protein homeostasis and reduces the biliary transcription factor SOX17, contributing to epithelial damage, lumen obstruction and fibrosis. It is a specialized tool for studying bile-duct development, cholangiocyte susceptibility and biliary atresia mechanisms.

Key Features

  • Reactive natural biliary toxin
  • Selectively damages extrahepatic cholangiocytes
  • Depletes glutathione and perturbs redox homeostasis
  • Reduces SOX17 signaling
  • Produces biliary-atresia-like pathology

Applications

  • Biliary atresia research
  • Cholangiocyte biology
  • Bile-duct development studies
  • Glutathione and redox-homeostasis assays
  • Zebrafish and neonatal mouse disease models

More Information

Parent CAS No. 1801433-90-8
Chemical Name 1-(4,6-Dimethoxybenzo[d][1,3]dioxol-5-yl)-2-(2-hydroxyphenyl)prop-2-en-1-one
SMILES C12OCOC=1C(OC)=C(C(C(C1C(O)=CC=CC=1)=C)=O)C(OC)=C2
MFCD N.A.
InChi InChI=1S/C18H16O6/c1-10(11-6-4-5-7-12(11)19)16(20)15-13(21-2)8-14-17(18(15)22-3)24-9-23-14/h4-8,19H,1,9H2,2-3H3
InChiKey SIKIIXNKUAAGAM-UHFFFAOYSA-N
CID 124079379
Short Description Natural toxin

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Axon Ligands™ for Cell Signaling & Oncology

Axon Ligand™ for Stem Cell Research 

Axon Ligands™ for Epigenetic Research 

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