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LY 334370 hydrochloride

Axon 1612
  • Parent CAS:  182563-08-2
Purity:  99%
  • Soluble in water and DMSO
  • MF:  C21H22FN3O.HCl
  • MW:  387.88

Description

LY 334370 hydrochloride is a selective serotonin 5-HT1F receptor agonist with reported Ki value of 1.87 nM.

5-HT1F receptor activation is pharmacologically relevant to migraine mechanisms because it can modulate trigeminal neurotransmission without vasoconstrictive 5-HT1B activity. LY 334370 is useful for studying 5-HT1F-selective agonism and migraine-related CNS pathways.

Key Features

  • Selective 5-HT1F receptor agonist
  • Reported Ki: 1.87 nM
  • Modulates trigeminal nociceptive signaling pathways
  • Useful for migraine mechanism research

Applications

  • 5-HT1F receptor pharmacology
  • Migraine pathway studies
  • Trigeminal nociception models
  • Serotonin GPCR agonist assays

More Information

Parent CAS No. 182563-08-2
Chemical Name 4-fluoro-N-(3-(1-methylpiperidin-4-yl)-1H-indol-5-yl)benzamide hydrochloride
SMILES N(C1C=CC2NC=C(C3CCN(C)CC3)C=2C=1)C(C1C=CC(F)=CC=1)=O.Cl
MFCD MFCD11519957
InChi InChI=1S/C21H22FN3O.ClH/c1-25-10-8-14(9-11-25)19-13-23-20-7-6-17(12-18(19)20)24-21(26)15-2-4-16(22)5-3-15;/h2-7,12-14,23H,8-11H2,1H3,(H,24,26);1H
InChiKey DGPDGAPZTPSHBL-UHFFFAOYSA-N
CID 19710026
Short Description 5-HT1F antagonist

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Axon Ligands™ for Cell Signaling & Oncology

Axon Ligand™ for Stem Cell Research 

Axon Ligands™ for Epigenetic Research 

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