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AR 231453
Axon 1572
CAS:
733750-99-7
Purity:
99%
- Soluble in DMSO
- MF: C21H24FN7O5S
- MW: 505.52
Description
AR 231453 is a potent and orally active agonist of the G protein-coupled receptor GPR119.
GPR119 activation in pancreatic beta cells and intestinal enteroendocrine cells can enhance insulin and incretin hormone signaling. AR 231453 is useful for investigating glucose-dependent insulin secretion, GLP-1 release and metabolic GPCR pharmacology.
Key Features
- Potent orally active GPR119 agonist
- Stimulates pathways linked to insulin and incretin release
- Relevant to type 2 diabetes and metabolic research
- Useful tool for enteroendocrine and beta-cell signaling studies
Applications
- GPR119 receptor pharmacology
- Glucose-stimulated insulin secretion assays
- GLP-1 and incretin biology studies
- Metabolic disease model research
More Information
| Parent CAS No. | 733750-99-7 |
|---|---|
| Chemical Name | N-(2-fluoro-4-methanesulfonylphenyl)-(6-[4-(3-isopropyl-[1,2,4]oxadiazol-5-yl)-piperidin-1-yl]-5-nitro-pyrimidin-4-yl)amine |
| SMILES | N1OC(C2CCN(C3N=CN=C(NC4C=CC(S(=O)(=O)C)=CC=4F)C=3[N+]([O-])=O)CC2)=NC=1C(C)C |
| MFCD | MFCD14706714 |
| InChi | InChI=1S/C21H24FN7O5S/c1-12(2)18-26-21(34-27-18)13-6-8-28(9-7-13)20-17(29(30)31)19(23-11-24-20)25-16-5-4-14(10-15(16)22)35(3,32)33/h4-5,10-13H,6-9H2,1-3H3,(H,23,24,25) |
| InChiKey | DGBKNTVAKIFYNU-UHFFFAOYSA-N |
| CID | 24939268 |
| Short Description | GPR119 agonist |
AR 231453
GPR119 agonist
Cannabinoids
GPR119
Agonist
GPCR signaling
GPR119 receptor pharmacology
Glucose-stimulated insulin secretion assays
GLP-1 and incretin biology studies
Metabolic disease model research
metabolism
diabetes research
GPCR pharmacology
signal transduction
receptor pharmacology
GPCR
CAS 733750-99-7
Axon Medchem
Axon 1572
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