TRPM8
For all organisms, detection and adaptation to cold temperature is crucial to survival. Cold sensing in the innocuous range of cold (>10-15 °C) in the mammalian peripheral nervous system is thought to rely primarily on transient receptor potential (TRP) ion channels, most notably the menthol receptor, TRPM8. The TRP cation channel, subfamily C member 5 (TRPC5), is found to be highly sensitive to cold in the temperature range 37–25 °C, and is thus hypothesized to play a role in sensing cold[1]. Additionally, the channel may have an important role in the pathogenesis of hypertension[2].
[1] K. Zimmermann et al. Transient receptor potential cation channel, subfamily C, member 5 (TRPC5) is a cold-transducer in the peripheral nervous system. Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18114-9.
[2] K.T. Cheng et al. Contribution and regulation of TRPC channels in store-operated Ca2+ entry. Curr Top Membr. 2013;71:149-79.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2423 | M8-B hydrochloride | Selective and potent antagonist of the TRPM8 channel | €115.00 | |
| 2483 | PF 05105679 | TRPM8 inhibitor with >100-fold selectivity and in vivo activity in humans | €95.00 | |
| 2498 | RQ 00203078 | Selective, potent, and orally active TRPM8 antagonist with in vivo activity | €125.00 | |