JavaScript seems to be disabled in your browser.
You must have JavaScript enabled in your browser to utilize the functionality of this website.

Axon Medchem

All

Home
Products
- Shop By Category
- Featured Products
- Shop By Alphabet
  - A
  - B
  - C
  - D
  - E
  - F
  - G
  - H
  - I
  - J
  - K
  - L
  - M
  - N
  - O
  - P
  - Q
  - R
  - S
  - T
  - U
  - V
  - W
  - X
  - Y
  - Z
  - #
Support
- - Customer Support
  - Customer Services
Contact
- About Axon Medchem
- Contact Us

Home
Products
Receptors
GPCR
Peptide
Thrombin (PAR)
SCH 79797 dihydrochloride

SCH 79797 dihydrochloride

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1275

CAS [1216720-69-2]

MF C23H25N5.2HCl
MW 444.40

Purity: 99%
Soluble in DMSO and Ethanol

SCH 79797 dihydrochloride

Description

Potent and selective non-peptide PAR1 antagonist.

KEYWORDS: SCH 79797 dihydrochloride | supplier | PAR1 antagonist | SCH79797 HCl | CAS [1216720-69-2] | [245520-69-8] | Thrombin | PAR | myocardial | ischemia | reperfusion | GPCR | protease-activated receptor 1 | apoptosis | airway | inflammation | fibrosis

JI Strande et al. SCH 79797, a selective PAR1 antagonist, limits myocardial ischemia/reperfusion injury in rat hearts. Bas. Res. Cardiol. 2007, 102(4), 350.

C di Serio et al. Protease-activated receptor 1-selective antagonist SCH79797 inhibits cell proliferation and induces apoptosis by a protease-activated receptor 1-independent mechanism. Bas. Clin. Pharmacol. Toxicol. 2007, 101(1), 63-69.

E Sokolova and G Reiser. A novel therapeutic target in various lung diseases: Airway proteases and protease-activated receptors. Pharmacol. Ther. 2007, 115(1), 70-83.

P Zania et al. Blockade of angiogenesis by small molecule antagonists to protease-activated receptor-1: association with endothelial cell growth suppression and induction of apoptosis. J. Pharm. Exp. Ther. 2006, 318(1), 246.

HS Ahn et al. Inhibition of cellular action of thrombin by N3-cyclopropyl-7-{[4-(1-methylethyl)phenyl]methyl}-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine (SCH 79797), a nonpeptide thrombin receptor antagonist. Biochem. Pharmacol. 2000, 60(10), 1425-1434.

List of publications using SCH 79797 dihydrochloride (Axon 1275) purchased from Axon Medchem

Cell Signaling & Oncology A15 Thrombin (PAR)

PAR1 antagonist

Chemical name

N*3*-Cyclopropyl-7-(4-isopropyl-benzyl)-7H-pyrrolo[3,2-f]quinazoline-1,3-diamine dihydrochloride

Parent CAS No.

[245520-69-8]

Order

Size	Unit Price	Stock
5 mg	€130.00	In Stock
25 mg	€520.00	In Stock

Need more? Bulk Inquiry

Related Products

Axon ID	Name	Description	From price
1622	GB83	PAR2 antagonist		€110.00
1755	SCH 530348	PAR1 antagonist		€150.00
1928	ML 161	Allosteric inhibitor of PAR1		€90.00
2030	E 5555 hydrobromide	Potent and orally active PAR1 antagonist		€115.00
2055	Q94 hydrochloride	Negative allosteric modulator of PAR1 (Gαq linkage)		€80.00
2647	Pirfenidone	Broad-spectrum anti-inflammatory and anti-fibrosis agent		€60.00
2898	AC 264613	Potent, selective, and metabolically stable PAR2 agonist		€95.00
3043	I-191	Potent PAR2 antagonist		€175.00
2899	ML354	Potent and selective PAR4 antagonist		€120.00

Please wait...