E 5555 hydrobromide - Atopaxar hydrobromide

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2030

CAS [474550-69-1]

MF C29H38FN3O5.HBr
MW 608.54

Purity: 99%
Soluble in DMSO

E 5555 hydrobromide

Description

Potent and orally active thrombin receptor (or protease-activated receptor 1, PAR1) antagonist (IC50: 19 nM); E5555 showed potent inhibitory effects on human platelet aggregation induced by thrombin and TRAP with IC50 values of 64 and 31nM, respectively

LV Serebruany et al. The in-vitro effects of E5555, a protease-activated receptor (PAR)-1 antagonist, on platelet biomarkers in healthy volunteers and patients with coronary artery disease. Thromb. Haemost. 2009, 102(1), 111-119.

S Goto et al. Double-blind, placebo-controlled Phase II studies of the protease-activated receptor 1 antagonist E5555 (atopaxar) in Japanese patients with acute coronary syndrome or high-risk coronary (...). Eur. Heart J. 2010, 31(21), 2601-2613.

M Kogushi et al. The novel and orally active thrombin receptor antagonist E5555 (Atopaxar) inhibits arterial thrombosis without affecting bleeding time in guinea pigs. Eur. J. Pharmacol. 2011, 657(1-3), 131-137.

Y Kai et al. Prevention of the hypercontractile response to thrombin by proteinase-activated receptor-1 antagonist in subarachnoid hemorrhage. Stroke. 2007 Dec;38(12):3259-65.

Potent and orally active PAR1 antagonist

Chemical name

1-(3-tert-butyl-4-methoxy-5-morpholinophenyl)-2-(5,6-diethoxy-7-fluoro-1-iminoisoindolin-2-yl)ethanone hydrobromide

Parent CAS No.

[751475-53-3]

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2 mg	€115.00	In Stock
5 mg	€175.00	In Stock
25 mg	€675.00	In Stock

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E 5555 hydrobromide - Atopaxar hydrobromide

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E 5555 hydrobromide - Atopaxar hydrobromide

Description

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Parent CAS No.

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