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Axon 3043
CAS [1690172-25-8]
MF C23H26FN5O2MW 423.48
I-191 is a potent antagonist of protease activated receptor 2 (PAR2) with a pIC50 value of 7.1 in HT-29 cells. I-191 potently attenuated multiple PAR2-mediated intracellular signaling pathways leading to Ca2+ release, ERK1/2 phosphorylation, RhoA activation and inhibition of forskolin-induced cAMP accumulation.
KEYWORDS: I-191 | supplier | PAR2 antagonist | PAR2 antagonist I-191 | I191 | I 191 | CAS [1690172-25-8] | Thrombin | Thrombin (PAR) | Antagonist | Receptors | MDK-2258
4-(8-tert-Butyl-6-(4-fluorophenyl)imidazo[1,2-b]pyridazine-2-carbonyl)-3,3-dimethylpiperazin-2-one
[1690172-25-8]
The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.
Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!
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