I-191 - PAR2 antagonist I-191

Based on 1 reference(s) in Google Scholar 8 10 1

Axon 3043

CAS [1690172-25-8]

MF C23H26FN5O2
MW 423.48

  • Purity: 98%
  • Soluble in DMSO



I-191 is a potent antagonist of protease activated receptor 2 (PAR2) with a pIC50 value of 7.1 in HT-29 cells. I-191 potently attenuated multiple PAR2-mediated intracellular signaling pathways leading to Ca2+ release, ERK1/2 phosphorylation, RhoA activation and inhibition of forskolin-induced cAMP accumulation.

KEYWORDS: I-191 | supplier | PAR2 antagonist | PAR2 antagonist I-191 | I191 | I 191 | CAS [1690172-25-8] | Thrombin | Thrombin (PAR) | Antagonist | Receptors | MDK-2258

Size Unit Price Stock
5 mg €175.00 In Stock
25 mg €475.00 In Stock
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The purity of Axon Ligands™ is confirmed by HPLC-MS, 1H-NMR and/or microanalysis. Analytical data are available upon request.

Caution: Axon Ligands™ are not fully tested. They are for research purposes only! Not for human consumption!

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