DGAT
Diacylglycerol O-acyltransferase 1 (DGAT1; EC 2.3.1.20) catalyzes the final step of the synthesis of triglycerides (TG) and plays a critical role in dietary fat absorption in the small intestine. Therefore, it is a potential therapeutic target for treatment of obesity and related metabolic diseases[1]. The co-enzyme Acyl-CoA is the donor substrate of the acetyl group that is transferred to the diglyceride substrates of DGAT1.
[1] Y. Hiramine, T. Tanabe. Characterization of acyl-coenzyme A:diacylglycerol acyltransferase (DGAT) enzyme of human small intestine. J. Physiol. Biochem. 2011, 67, 259-264.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2059 | A 922500 | Highly potent and selective diacylglycerol acyltransferase 1 (DGAT-1) inhibitor | €105.00 | |
| 3823 | Ervogastat | Potent and selective diacylglycerol acyltransferase 2 (DGAT-2) inhibitor | €160.00 | |