SC 26196 - PF 06341724

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 2112

CAS [218136-59-5]

MF C27H29N5
MW 423.55

Purity: 99%
Soluble in DMSO

SC 26196

Description

Selective Δ6-desaturase inhibitor (IC50 = 0.2 µM in vitro; >100 fold selective over Δ5- and Δ9-desaturases), an enzyme essential for the synthesis of arachidonic acid. It showed anti-inflammatory effects to the same extent as indomethacin or essential fatty acid deficiency in established mouse models

MG Obukowicz et al. Novel, selective delta6 or delta5 fatty acid desaturase inhibitors as antiinflammatory agents in mice. J. Pharmacol. Exp. Ther. 1998, 287(1), 157-166.

MB Hansen-Petrik et al. Selective inhibition of Delta-6 desaturase impedes intestinal tumorigenesis. Cancer Lett. 2002, 175(2), 157-163.

Selective Δ6-desaturase inhibitor

Chemical name

2,2-diphenyl-5-(4-(pyridin-3-ylmethyleneamino)piperazin-1-yl)pentanenitrile

Parent CAS No.

[218136-59-5]

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5 mg	€85.00	In Stock
25 mg	€285.00	In Stock

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Size	Unit Price	Stock
2 x 5 mg	€130.00	In Stock
2 x 25 mg	€460.00	In Stock

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SC 26196 - PF 06341724

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SC 26196 - PF 06341724

Description

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