Remogliflozin - GSK 189074

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1634

CAS [329045-45-6]

MF C23H34N2O7
MW 450.53

Purity: 99%
Soluble in water and DMSO

Remogliflozin

Description

Remogliflozin inhibits the sodium-glucose transport (SGLT2) proteins, which are responsible for glucose reabsorption in the kidney. Blocking this transporter causes blood glucose to be eliminated through the urine. Its prodrug is Remoglifozin etabonate (GSK 189075), investigated as a treatment of anti diabetes type II

Y Fujimori et al. Remogliflozin Etabonate, in a Novel Category of Selective Low-Affinity Sodium Glucose Cotransporter (SGLT2) Inhibitors, Exhibits Antidiabetic Efficacy in Rodent Models. J. Pharmacol. Exp. Ther. 2008, 327(1), 268-276.

Diabetes & Metabolism SGLT2 Sodium-Glucose Co-transproter

SGLT2 inhibitor

Chemical name

(2R,3S,4S,5R,6S)-2-(hydroxymethyl)-6-(4-(4-isopropoxybenzyl)-1-isopropyl-5-methyl-1H-pyrazol-3-yloxy)tetrahydro-2H-pyran-3,4,5-triol

Parent CAS No.

[329045-45-6]

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