Forkhead box (Fox) proteins are a family of evolutionarily conserved transcriptional regulators defined by a common DNA-binding domain (DBD) termed the forkhead box or winged helix domain[1]. The transcription factor FOXM1 (TF class 3.3.1) specifically binds to sequence-specific motifs on DNA (C/TAAACA) and activates proliferation- and differentiation-associated genes critical to mitotic spindle assembly, chromosome segregation and G2/M transition, with depletion leading to cell cycle arrest. Aberrant upregulation of FOXM1 has been shown to be a key driver of cancer progression and has been proposed as an initiating factor of oncogenesis. Furthermore, FOXM1 overexpression has been implicated in the development of chemotherapeutic resistance in human breast cancer[2].