The Eph receptor tyrosine kinases (RTK class XIII, EPH receptor family) and their ephrin ligands have intriguing expression patterns in cancer cells and tumor blood vessels, which suggest important roles for their bidirectional signals in many aspects of cancer development and progression[1]. They have been shown to affect the growth, migration and invasion of cancer cells in culture as well as tumor growth, invasiveness, angiogenesis and metastasis in vivo.