The transient receptor potential ankyrin-repeat 1 (TRPA1) channel  is the sole member of  the TRPA branch of the TRP ion channel gene family. TRPA channels resemble TRPN channels that were implicated in mechanotransduction and hearing in Drosophila and zebrafish. However, the ion channel domain of TRPA channels is evolutionarily distant from TRPN channels[1]. TRPA1 channels are required for neuronal excitation, the release of inflammatory neuropeptides, and subsequent pain hypersensitivity[2]. TRPA1 is also activated by the release of inflammatory agents from nonneuronal cells in the area of tissue injury or disease, and by environmental irritants and pungent chemicals, such as cinnamaldehyde and mustard oil. Extracellular Ca²⁺ is a key regulator of TRPA1 activity, both potentiating and subsequently inactivating it[3].