LB 42708

Based on 20 reference(s) in Google Scholar 80 100 20

Axon 1794

CAS [226929-39-1]

MF C30H27BrN4O2
MW 555.46

Purity: 99%
Soluble in DMSO

LB 42708

Description

Selective and orally available inhibitor of farnesyltransferase (FTase), with IC50 values of 0.8 nM in vitro and 8 nM in cultured cells against p21-ras farnesylation

HJ Na et al. Inhibition of Farnesyltransferase Prevents Collagen-Induced Arthritis by Down-Regulation of Inflammatory Gene Expression through Suppression of p21ras-Dependent NF-κB Activation. J. Immunol. 2004, 173, 1276-1283.

CK Kim et al. The farnesyltransferase inhibitor LB42708 suppresses vascular endothelial growth factor-induced angiogenesis by inhibiting Ras-dependent mitogen-activated protein kinase and PI3K/Akt signal pathways. Mol. Pharmacol. 2010, 78, 142-150.

Inhibitor of farnesyltransferase (FTase)

Chemical name

(1-((1-(4-bromobenzyl)-1H-imidazol-5-yl)methyl)-4-(naphthalen-1-yl)-1H-pyrrol-3-yl)(morpholino)methanone

Parent CAS No.

[226929-39-1]

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5 mg	€95.00	In Stock
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LB 42708

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