List of publications using PD184352 (Axon 1368) purchased from Axon Medchem
(Total 47 publication citations until AUGUST-2017)
Morales, Aixa V., et al. "FGF signaling enhances a sonic hedgehog negative feedback loop at the initiation of spinal cord ventral patterning." Developmental neurobiology (2015).
Scalable Electrophysiological Investigation of iPS Cell-Derived Cardiomyocytes Obtained by a Lentiviral Purification Strategy.
Friedrichs, S., Malan, D., Voss, Y., & Sasse, P. (2015).
J. Clin. Med. 2015, 4(1), 102-123; doi:10.3390/jcm4010102
*CHIR99021 and PD184352 from Axon Medchem.
2014
The MAPK pathway as an apoptosis enhancer in melanoma.
Haydn, J. M., Hufnagel, A., Grimm, J., Maurus, K., Schartl, M., & Meierjohann, S.
Oncotarget. 2014 Jul 15;5(13):5040-53.
*PD184352 and GDC-0941 were purchased from Axon Medchem
The Immune Microenvironment Confers Resistance to MAPK Pathway Inhibitors through Macrophage-Derived TNFα.
Smith, M. P., Sanchez-Laorden, B., O'Brien, K., Brunton, H., Ferguson, J., Young, H., ... & Wellbrock, C. (2014).
Cancer Discov. 2014 Oct;4(10):1214-29. doi: 10.1158/2159-8290.CD-13-1007.
Transcriptomic analysis of mouse limb tendon cells during development.
Havis, E., Bonnin, M. A., Olivera-Martinez, I., Nazaret, N., Ruggiu, M., Weibel, J., ... & Duprez, D. (2014).
Development. 2014 Oct;141(19):3683-96. doi: 10.1242/dev.108654. Epub 2014 Sep 5.
FGFR4 signaling couples to bim and not bmf to discriminate subsets of alveolar rhabdomyosarcoma cells
M Wachtel, J Rakic, M Okoniewski, P Bode, F Niggli, BW Schafer.
Int J Cancer. 2014 Oct 1;135(7):1543-52. doi: 10.1002/ijc.28800. Epub 2014 Mar 3.
Polyspermy block in jellyfish eggs: Collaborative controls by Ca2+ and MAPK.
Arakawa, M., Takeda, N., Tachibana, K., & Deguchi, R.
Developmental biology. Available online 6 May 2014
Read more: http://dx.doi.org/10.1016/j.ydbio.2014.04.020
INDUCED MALIGNANT STEM CELLS.
Ishikawa, Tetsuya. 2014.
U.S. Patent No. 20140137274(A1).
Identification of protein kinase inhibitors with a selective negative effect on the viability of Epstein-Barr virus infected B cell lines.
Mavromatidis, V., Varga, Z., Waczek, F., Őrfi, Z., Őrfi, L., Kéri, G., & Mosialos, G. (2014).
PLoS One. 2014 Apr 23;9(4):e95688. doi: 10.1371/journal.pone.0095688. eCollection 2014.
* PD1784352 and A770041 from Axon Medchem
Brf1 posttranscriptionally regulates pluripotency and differentiation responses downstream of Erk MAP kinase.
Tan, F. E., & Elowitz, M. B. (2014).
Proc Natl Acad Sci U S A. 2014 Apr 29;111(17):E1740-8. doi: 10.1073/pnas.1320873111. Epub 2014 Apr 14.
Compounds and compositions as protein kinase inhibitors.
Costales, A. Q., Huang, S., Jin, J. X., Liu, Z., Pecchi, S., Poon, D., ... & Zhang, Q. 2014.
U.S. Patent No. 8859548 (B2).
*PD0325901 and other 11 drugs from Axon Medchem, including PD184352, SL327, LY294002, PI103, PIK75, PIK90, GDC0941, BEZ235, AS252424 and TGX221.
Isolated naive pluripotent stem cells and methods of generating same.
Hanna, Yaqub, Noa Novershtern, and Yoach Rais. 2014.
US Patent No. US 20140315301 (A1)
*PD184352, CHIR99021 and PD0325901 and 20 other compounds from Axon Medchem
2013
HETEROARYL COMPOUNDS AND COMPOSITIONS AS PROTEIN KINASE INHIBITORS.
AM Madera, D Poon, A Smith. 2013.
U.S. Patent 20130096149 (A1).
*10 drugs from Axon Medchem have been tested
mTOR complex 2 phosphorylates IMP1 cotranslationally to promote IGF2 production and the proliferation of mouse embryonic fibroblasts.
N Dai, J Christiansen, FC Nielsen, & J Avruch.
Genes Dev. 2013 Feb 1;27(3):301-12. doi: 10.1101/gad.209130.112.
Effect of SMURF2 targeting on susceptibility to MEK Inhibitors in melanoma.
Smith, M. P., Ferguson, J., Arozarena, I., Hayward, R., Marais, R., Chapman, A., ... & Wellbrock, C.
J Natl Cancer Inst. 2013 Jan 2;105(1):33-46. doi: 10.1093/jnci/djs471. Epub 2012 Dec 17.
Characteristics of Bovine Inner Cell Mass-Derived Cell Lines and Their Fate in Chimeric Conceptuses.
T Furusawa, K Ohkoshi, K Kimura, S Matsuyama, S Akagi, M Kaneda, M Ikeda, M Hosoe, K Kizaki, and T Tokunaga.
Biol Reprod. 2013 Aug 8;89(2):28. doi: 10.1095/biolreprod.112.106641. Print 2013 Aug.
(* CHIR99021 and PD184352 both from Axon Medchem)
The function of the Heg-CCM pathway in zebrafish heart development.
JN Rosen, 2013.
PhD thesis Harvard University
*CI-1040 (Axon 1368, PD184352) used in this study.
Combination of MEK and SRC inhibition suppresses melanoma cell growth and invasion.
Ferguson, J., Arozarena, I., Ehrhardt, M., & Wellbrock, C.
Oncogene. 2013 Jan 3;32(1):86-96. doi: 10.1038/onc.2012.25. Epub 2012 Feb 6.
Phosphorylation of STIM1 at ERK1/2 target sites regulates interaction with the microtubule plus-end binding protein EB1
Pozo-Guisado, E., Casas-Rua, V., Tomas-Martin, P., Lopez-Guerrero, A. M., Alvarez-Barrientos, A., & Martin-Romero, F. J.
J Cell Sci. 2013 Jul 15;126(Pt 14):3170-80. doi: 10.1242/jcs.125054. Epub 2013 May 17.
2012
ERK5 promotes, whereas MEK1 differentially regulates, the Toll-like Receptor 2-dependent activation of human endothelial cells and monocytes.
Wilhelmsen, K., Mesa, K. R., Lucero, J., Xu, F., & Hellman, J.
J Biol Chem. 2012 Aug 3;287(32):26478-94. doi: 10.1074/jbc.M112.359489. Epub 2012 Jun 15.
The double-stranded RNA bluetongue virus induces type I interferon in plasmacytoid dendritic cells via a MYD88-dependent TLR7/8-independent signaling pathway.
Ruscanu, S., Pascale, F., Bourge, M., Hemati, B., Elhmouzi-Younes, J., Urien, C., ... & Schwartz-Cornil, I.
J Virol. 2012 May;86(10):5817-28. doi: 10.1128/JVI.06716-11. Epub 2012 Mar 21.
MEK/Erk-based negative feedback mechanism involved in control of Steel Factor-triggered production of Krüppel-like factor 2 in mast cells.
Marschall, J. S., Wilhelm, T., Schuh, W., & Huber, M.
Cell Signal. 2012 Apr;24(4):879-88. doi: 10.1016/j.cellsig.2011.12.007. Epub 2011 Dec 13.
Novel zebrafish model reveals a critical role for MAPK in lymphangiogenesis.
RD Fevurly, S Hasso, A Fye, SJ Fishman, J Chan.
J Pediatr Surg. 2012 Jan;47(1):177-82. doi: 10.1016/j.jpedsurg.2011.10.035.
Optimal induction of myeloma cell death requires dual blockade of phosphoinositide 3-kinase and mTOR signalling and is determined by translocation subtype.
Stengel, C., Cheung, C. W., Quinn, J., Yong, K., & Khwaja, A. - nature.com -
Leukemia. 2012 Aug;26(8):1761-70. doi: 10.1038/leu.2012.69. Epub 2012 Mar 14.
Combined targeting of MEK/MAPK and PI3K/Akt signalling in multiple myeloma.
Steinbrunn, T., Stühmer, T., Sayehli, C., Chatterjee, M., Einsele, H., & Bargou, R. C.
Br J Haematol. 2012 Nov;159(4):430-40. doi: 10.1111/bjh.12039. Epub 2012 Sep 17.
Telomere elongation during morula-to-blastocyst transition in cloned porcine embryos.
Dang-Nguyen, T. Q., Haraguchi, S., Akagi, S., Somfai, T., Kaneda, M., Watanabe, S., ... & Nagai, T. (2012).
Cell Reprogram. 2012 Dec;14(6):514-9. doi: 10.1089/cell.2012.0045.
Establishment of self-renewing porcine embryonic stem cell-like cells by signal inhibition.
Haraguchi S, Kikuchi K, Nakai M, Tokunaga T.
J Reprod Dev. 2012;58(6):707-16. Epub 2012 Sep 7.
METHOD FOR CONSTRUCTING CHIMERIC RAT USING RAT EMBRYONIC STEM CELLS.
Ochiya, T., & Kawamata, M. (2012).
U.S. Patent No. 2012272349 (A1)
2011
Coordinated waves of gene expression during neuronal differentiation of embryonic stem cells as basis for novel approaches to developmental neurotoxicity testing.
B Zimmer, PB Kuegler, B Baudis, A Genewsky, V Tanavde , W Koh , B Tan , T Waldmann , S Kadereit , M Leist. - nature.com
Cell Death Differ. 2011 Mar;18(3):383-95. doi: 10.1038/cdd.2010.109. Epub 2010 Sep 24.
Regulation of autophagic activity by 14-3-3ζ proteins associated with class III phosphatidylinositol-3-kinase.
M Pozuelo-Rubio - nature.com
Cell Death Differ. 2011 Mar;18(3):479-92. doi: 10.1038/cdd.2010.118. Epub 2010 Oct 1.
Mutated RAS and constitutively activated Akt delineate distinct oncogenic pathways, which independently contribute to multiple myeloma cell survival.
T Steinbrunn, T Stühmer, S Gattenlöhner, A Rosenwald, A Mottok, C Unzicker, H Einsele, M Chatterjee, RC Bargou.
Blood. 2011 Feb 10;117(6):1998-2004. doi: 10.1182/blood-2010-05-284422. Epub 2010 Dec 13.
2010
Neuronatin Promotes Neural Lineage in ESCs via Ca2+ Signaling.
HH Lin, E Bell, D Uwanogho, LW Perfect, H Noristani, TJD Bates, V Snetkov, J Price, YM Suu.
Stem Cells. 2010 Nov;28(11):1950-60. doi: 10.1002/stem.530.
Constitutive MEK1 activation rescues anthrax lethal toxin-induced vascular effects in vivo.
RE Bolcome III, J Chan - Infection and immunity, 2010 - Am Soc Microbiol
Infect Immun. 2010 Dec;78(12):5043-53. doi: 10.1128/IAI.00604-10. Epub 2010 Sep 20.
Erucylphosphohomocholine, the first intravenously applicable alkylphosphocholine, is cytotoxic to acute myelogenous leukemia cells through JNK- and PP2A-dependent mechanisms.
AM Martelli, V Papa, PL Tazzari, F Ricci, C Evangelisti, F Chiarini, C Grimaldi, A Cappellini, G Martinelli, E Ottaviani, P Pagliaro, S Horn, J Bäsecke, LH Lindner, H Eibl, JA McCubrey.
Leukemia. 2010 Apr;24(4):687-98. doi: 10.1038/leu.2010.32. Epub 2010 Mar 4.
MMP13 mediates cell cycle progression in melanocytes and melanoma cells: in vitro studies of migration and proliferation.
S Meierjohann, A Hufnagel, E Wende, MA Kleinschmidt, K Wolf, P Friedl, S Gaubatz and M Schartl.
Mol Cancer. 2010 Jul 28;9:201. doi: 10.1186/1476-4598-9-201.
Poly (ADP-ribose) polymerase 1 modulates the lethality of CHK1 inhibitors in carcinoma cells.
C Mitchell, M Park, P Eulitt, C Yang, A Yacoub, P Dent.
Mol Pharmacol. 2010 Nov;78(5):909-17. doi: 10.1124/mol.110.067199. Epub 2010 Aug 9.
Phosphorylation of STIM1 at ERK1/2 target sites modulates store-operated calcium entry.
E Pozo-Guisado, DG Campbell, M Deak, A Álvarez-Barrientos, NA Morrice, IS Álvarez, DR Alessi, FJ Martín-Romero.
J Cell Sci. 2010 Sep 15;123(Pt 18):3084-93. doi: 10.1242/jcs.067215. Epub 2010 Aug 24.
2009
A Twist-Snail axis critical for TrkB-induced epithelial-mesenchymal transition-like transformation, anoikis resistance, and metastasis.
MA Smit, TR Geiger, JY Song, I Gitelman, DS Peeper.
Mol Cell Biol. 2009 Jul;29(13):3722-37. doi: 10.1128/MCB.01164-08. Epub 2009 May 4.
Identification of Novel in Vivo Phosphorylation Sites of the Human Proapoptotic Protein BAD.
L Polzien, A Baljuls, UEE Rennefahrt, A Fischer… W Schmitz, RP Zahedi, A Sickmann, R Metz, S Albert, R Benz, M Hekman, UR Rapp
J Biol Chem. 2009 Oct 9;284(41):28004-20. doi: 10.1074/jbc.M109.010702. Epub 2009 Aug 10.
Extracellular growth factors and mitogens cooperate to drive mitochondrial biogenesis.
P Echave, G Machado-da-Silva, RS Arkell, MR Duchen, J Jacobson, R Mitter, AC Lloyd.
J Cell Sci. 2009 Dec 15;122(Pt 24):4516-25. doi: 10.1242/jcs.049734. Epub 2009 Nov 17.
(This is an incomplete list, updated in AUGUST-2017)
