NO and HNO donors

Comparisons of the pharmacological effects of nitric oxide (NO) and nitroxyl (HNO) donors have demonstrated that the responses to these redox-related nitrogen oxides are nearly universally dissimilar. These analyses have suggested the existence of mutually exclusive signaling pathways as a result of discrete chemical interactions of HNO and NO with a variety of critical biomolecules. The pharmacological responses to HNO are promising for clinical treatment of cardiovascular diseases such as heart failure, myocardial infarction and stroke[1].


[1] KM Miranda. Donors of HNO. Curr Top Med Chem. 2005;5(7):649-64.

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2653 CXL-1020 HNO donor which may be useful for the treatment of heart failure. Inquire

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