Autophagy is a process where cellular components such as macroproteins or even whole organelles are sequestered into lysosomes for degradation. The lysosomes are then able to digest these substrates, the components of which can either be recycled to create new cellular structures and/or organelles or alternatively can be further processed and used as a source of energy. To date, three distinct forms of autophagy have been identified - macroautophagy, microautophagy and selective autophagy. Failure of autophagy as well as potentially allowing the development of cancer has also been associated (particularly in aged organisms) with the accumulation of protein aggregates in the neurons and the development of neurodegenerative conditions including Alzheimer's disease[1]

[1] MS D'Arcy. Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 2019 Apr 8.

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Axon ID Name Description From price
2894 STF 62247 Inducer of apoptosis and autophagy in VHL-deficient RCC cells €85.00
2512 Spautin 1 Inhibitor of USP10 and USP13 and Beclin1 related autophagy €95.00
2627 SMER 28 Small molecule enhancer of rapamycin that enhances autophagy €80.00
2902 QX77 Chaperone-mediated autophagy (CMA) activator €120.00
2932 MSL-7 Autophagy enhancer €115.00
2425 MHY 1485 mTOR activator with an inhibitory effect on autophagy €70.00
3843 LYN-1604 dihydrochloride Potent ULK1 agonist €130.00
3426 IU1-47 Potent and selective inhibitor deubiquitinase USP14 €80.00
3429 Indophagolin Potent autophagy inhibitor €130.00
2933 IITZ-01 Potent lysosomotropic autophagy inhibitor €125.00
4149 Everolimus Selective and orally active mTOR1 inhibitor Inquire
4072 Doxorubicin hydrochloride A cytotoxic anthracycline antibiotic Inquire
3580 DC-LC3in-D5 Autophagy inhibitor €140.00
3906 CA77.1 Orally bioavailable and brain-penetrant CMA activator €90.00
2679 AR7 RARα antagonist that stimulates chaperone-mediated autophagy €90.00

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