Autophagy
Autophagy is a process where cellular components such as macroproteins or even whole organelles are sequestered into lysosomes for degradation. The lysosomes are then able to digest these substrates, the components of which can either be recycled to create new cellular structures and/or organelles or alternatively can be further processed and used as a source of energy. To date, three distinct forms of autophagy have been identified - macroautophagy, microautophagy and selective autophagy. Failure of autophagy as well as potentially allowing the development of cancer has also been associated (particularly in aged organisms) with the accumulation of protein aggregates in the neurons and the development of neurodegenerative conditions including Alzheimer's disease[1].
[1] MS D'Arcy. Cell death: a review of the major forms of apoptosis, necrosis and autophagy. Cell Biol Int. 2019 Apr 8.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 2679 | AR7 | RARα antagonist that stimulates chaperone-mediated autophagy | €90.00 | |
| 3906 | CA77.1 | Orally bioavailable and brain-penetrant CMA activator | €90.00 | |
| 4072 | Doxorubicin hydrochloride | A cytotoxic anthracycline antibiotic | Recently added | Inquire |
| 2933 | IITZ-01 | Potent lysosomotropic autophagy inhibitor | €125.00 | |
| 3429 | Indophagolin | Potent autophagy inhibitor | €130.00 | |
| 3426 | IU1-47 | Potent and selective inhibitor deubiquitinase USP14 | €80.00 | |
| 3843 | LYN-1604 dihydrochloride | Potent ULK1 agonist | €130.00 | |
| 2425 | MHY 1485 | mTOR activator with an inhibitory effect on autophagy | €70.00 | |
| 2932 | MSL-7 | Autophagy enhancer | €115.00 | |
| 2902 | QX77 | Chaperone-mediated autophagy (CMA) activator | €120.00 | |
| 2627 | SMER 28 | Small molecule enhancer of rapamycin that enhances autophagy | €80.00 | |
| 2512 | Spautin 1 | Inhibitor of USP10 and USP13 and Beclin1 related autophagy | €95.00 | |
| 2894 | STF 62247 | Inducer of apoptosis and autophagy in VHL-deficient RCC cells | €85.00 | |