Transcription Factors
Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].
[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.
| Axon ID | Name | Description | From price | |
|---|---|---|---|---|
| 1863 | CID 5951923 | Inhibitor of Krüppel-like factor 5 (KLF5) | €135.00 | |
| 3035 | Compound 10 |
Tool compound targeting the NFAT:AP-1 transcriptional complex on DNA. |
€150.00 | |
| 2879 | CP 31398 | Stabilizer of p53 and inducer of apoptosis | €100.00 | |
| 3518 | DCZ0805 | NF-κB activation inhibitor | €130.00 | |
| 2080 | EVP 4593 | NF-κB activation inhibitor; inhibits SOC pathway | €110.00 | |
| 2349 | JSH 23 | Inhibitor of NF-κB transcription and nuclear translocation of p65 without affecting IκBα degradation | €95.00 | |
| 3270 | Lj-1-60 | Fyn inhibitor targeting the Fyn/Stat3 pathway | €90.00 | |
| 3607 | Micheliolide | NF-κB activation inhibitor | €120.00 | |
| 3387 | NF-κB Activation Inhibitor IV | Potent NF-κB activation inhibitor | €90.00 | |
| 3909 | NFATc1 inhibitor A04 | Potent RANKL-induced osteoclastogenesis inhibitor | €90.00 | |
| 3277 | NSC194598 | p53 DNA-binding inhibitor | €130.00 | |
| 3614 | Parthenolide | NF-κB activation inhibitor | €90.00 | |
| 1871 | Pifithrin-α hydrobromide | Inhibitor of p53 protein | €95.00 | |
| 3051 | Pifithrin-β | Inhibitor of p53 protein; Condensation product of Pifithrin-α | €95.00 | |
| 3520 | PY108 | Potent, orally bioavailable AHR agonist | €120.00 | |
| 3521 | PY109 | Potent, orally bioavailable AHR agonist | €120.00 | |
| 1701 | Shz-1 | Stem cell differentiating agent; Nkx2.5 inducer | €95.00 | |
| 1865 | Stemregenin 1 | Aryl hydrocarbon receptor (AHR) antagonist | €105.00 | |