Transcription Factors

Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].

[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.

17 Item(s)

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Axon ID Name Description From price
1863 CID 5951923 Inhibitor of Krüppel-like factor 5 (KLF5) €135.00
3035 Compound 10

Tool compound targeting the NFAT:AP-1 transcriptional complex on DNA.

2879 CP 31398 Stabilizer of p53 and inducer of apoptosis €95.00
3518 DCZ0805 NF-κB activation inhibitor €130.00
2080 EVP 4593 NF-κB activation inhibitor; inhibits SOC pathway €110.00
2349 JSH 23 Inhibitor of NF-κB transcription and nuclear translocation of p65 without affecting IκBα degradation €95.00
3270 Lj-1-60 Fyn inhibitor targeting the Fyn/Stat3 pathway €90.00
3607 Micheliolide NF-κB activation inhibitor €120.00
3387 NF-κB Activation Inhibitor IV Potent NF-κB activation inhibitor €90.00
3277 NSC194598 p53 DNA-binding inhibitor €130.00
3614 Parthenolide NF-κB activation inhibitor €90.00
1871 Pifithrin-α hydrobromide Inhibitor of p53 protein €95.00
3051 Pifithrin-β Inhibitor of p53 protein; Condensation product of Pifithrin-α €95.00
3520 PY108 Potent, orally bioavailable AHR agonist €120.00
3521 PY109 Potent, orally bioavailable AHR agonist €120.00
1701 Shz-1 Stem cell differentiating agent; Nkx2.5 inducer €95.00
1865 Stemregenin 1 Aryl hydrocarbon receptor (AHR) antagonist €105.00

17 Item(s)

per page
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