Transcription Factors

Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].


[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.

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Axon ID Name Description From price
2379 ZLN 005 Selective transcriptional regulator of peroxisome PPAR-γ coactivator-1α (PGC-1α). €45.00
2469 YK 4-279 Inhibitor of ETV1, ERG and interactions of EWS-FLI1 and RNA helicase A €95.00
2316 WP 1066 Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins €95.00
2249 Tenovin 6 Small water soluble p53 activator and SIRT inhibitor €105.00
1865 Stemregenin 1 Aryl hydrocarbon receptor (AHR) antagonist €105.00
2314 Stattic Nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation €50.00
2731 STAT5 Inhibitor 1 [285986-31-4] Nonpeptidic small-molecule inhibitor of STAT5 activation €90.00
2764 SIS3 Potent and selective inhibitor of Smad3 and TGF-βR1 signaling €135.00
1701 Shz-1 Stem cell differentiating agent; Nkx2.5 inducer €95.00
2244 SCH 529074 Small molecule activator of mutant p53. €100.00
2313 S3I 201 Potent, cellular STAT3 inhibitor €95.00
2497 RTA 408 Triterpenoid activator of NRF2 and inhibitor of NF-κB €110.00
2488 Piperlongumine Natural alkaloid with potent cytotoxic activity €65.00
1871 Pifithrin-α hydrobromide Inhibitor of p53 protein €95.00
2651 OAC2 Oct4 and Nanog activating compound that enhances reprogramming efficiency €60.00

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