Proteins belonging to the NFAT (nuclear factor of activated T cells) family of transcription factors play a central role in inducible gene transcription during the immune response[1]. The NFAT family consists of five members: NFAT1 (also known as NFATp or NFATc2), NFAT2 (also known as NFATc or NFATc1), NFAT3 (also known as NFATc4), NFAT4 (also known as NFATx or NFATc3) and NFAT5. Four of these proteins are regulated by calcium signalling[2]. Despite their name, NFAT proteins are expressed not only in T cells, but also in other classes of immune-system cells[1]. NFAT directs the effector arm of the immune response in the presence of activator protein-1 (AP-1), and T cell anergy/exhaustion in the absence of AP-1[3].

[1] A Rao et al. Transcription factors of the NFAT family: regulation and function. Annu Rev Immunol. 1997;15:707-47.
[2] F Macian. NFAT proteins: key regulators of T-cell development and function. Nat Rev Immunol. 2005 Jun;5(6):472-84.
[3] GP Mognol et al. Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor. Proc Natl Acad Sci U S A. 2019 May 14;116(20):9959-9968.

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Axon ID Name Description From price
3909 NFATc1 inhibitor A04 Potent RANKL-induced osteoclastogenesis inhibitor €90.00
3035 Compound 10

Tool compound targeting the NFAT:AP-1 transcriptional complex on DNA.


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