p53

Transcription factors (TFs) are key cellular components that control the first step of gene expression, the transcription of DNA into RNA sequences. By ensuring the correct expression of specific genes, the transcriptional regulatory system plays a central part in controlling many biological processes, ranging from cell cycle progression and maintenance of intracellular metabolic and physiological balance, to cellular differentiation and developmental time courses. TFs may be constitutively active or conditionally active. The most common classification of TFs is based on the structure of their DNA-binding domains. Grouping TFs by structural domain has been extremely useful in uncovering how they recognize and bind specific DNA sequences, as well as providing insights into their evolutionary histories. Moreover, in some instances the DNA-binding domain provides clues to their function[1]. A comprehensive classification recognizes four superfamilies with well-defined structural homology: basic domains TFs (1), Zinc-coordinating domains TFs (2), helix-turn-helix (HTH) domains TFs (3), and beta-scaffold domains with Minor Groove Contacts TFs (4). Additionally, a fifth family of orphan TFs exists for which no superclass assignment can be done yet because of lack of structural information[2].
This superfamily of transcription factors with β-scaffold DNA-binding domains with minor groove contacts comprises 11 subclasses: RHR, STAT, p53,  MADS box, β-Barrel α-helix transcription factors, TATA binding proteins, HMG-box, Heteromeric CCAAT factors, grainyhead, Cold-shock domain factors, and Runt[3]. Late SV40 Factor (LSF), also known as alpha-globin transcription factor CP2 (TFCP2), functions as part of the SSP(stage selector protein) complex, and binds a variety of cellular and viral promoters including fibrinogen, alpha-globin, SV40 and HIV-1 promoters[4].


[1] J.M. Vaquerizas et al. A census of human transcription factors: function, expression and evolution. Nat. Rev. Genetics 2009, 10, 252-263.
[2] P. Stegmaier, A.E. Kel, E. Wingender. SystematicDNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.
[3] P. Stegmaier, A.E. Kel, E. Wingender. Systematic DNA-binding domain classification of transcription factors. Genome Inform. 2004, 15, 276-286.
[4] P.K. Santhekadur et al. The transcription factor LSF: a novel oncogene for hepatocellular carcinoma. Am. J. Cancer Res. 2012, 2, 269-285. 

8 Item(s)

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Axon ID Name Description From price
2157 FQI 1 Inhibitor of α-globin transcription factor CP2 (LSF) €95.00
2319 L 002 Inhibitor of p300 HAT (KAT3B) and p53 acetylation €80.00
2016 NSC 319726 Reactivator of the p53 mutant p53R175 €105.00
1402 NSC 348884 NPM inhibitor €120.00
2564 NSC 59984 Activator of p53 that restores WT p53 signaling via p73 activation €95.00
1871 Pifithrin-α hydrobromide Inhibitor of p53 protein €95.00
2244 SCH 529074 Small molecule activator of mutant p53. €100.00
2249 Tenovin 6 Small water soluble p53 activator and SIRT inhibitor €105.00

8 Item(s)

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