Sex-determining Region Y (SRY) box 9 (SOX-9; TF 4.7.1) is a member of a highly conserved family of transcription factors defined by their similarity to the high mobility group DNA-binding domain of SRY (HMG-box family). It is crucial for multiple aspects of development, such as regulating the production of extracellular matrix (ECM) cartilage and cell proliferation, among others[1]. SOX-9 is also expressed in a wide range of cancers, where it regulates cell proliferation. Functionally, SOX-9 knockdown impairs cell proliferation in glioma cell lines, induces the cell arrest in G2/M phase of cell cycle and enhances the apoptosis in glioma cells. The inhibition of its activity mediates the impaired cell cycle progression and reduced cell invasion induced by miR-145 tumor suppressor[2].