YAP

YAP and TAZ proteins are transcriptional coactivators, which shuttle between the cytoplasm and the nucleus in response to multiple inputs, including the Hippo pathway. In the nucleus, they pair with DNA-binding factors of the TEAD family to regulate gene expression. Nuclear YAP/TAZ promote cell proliferation, organ overgrowth, survival to stress and dedifferentiation of post-mitotic cells into their respective tissue progenitors. YAP/TAZ are required for growth of embryonic tissues, wound healing and organ regeneration, where they are activated by cell-intrinsic and extrinsic cues.[1]


[1] A Pocaterra et al. YAP/TAZ functions and their regulation at a glance. J Cell Sci. 2020 Jan 29;133(2):jcs230425.

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Axon ID Name Description From price
3276 TRULI LATS1/2 inhibitor €120.00
3354 Verteporfin Inhibitor of TEAD–YAP association; Photosensitizer €90.00

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