Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
5052 Axon Ligands™ Epigenetic compound library Axon Ligands™ Epigenetic compound library Inquire
5053 Axon Ligands™ Stem cell compound library Axon Ligands™ Stem cell compound library Inquire
2345 AZ 20 Potent, orally active and selective inhibitor of ATR protein kinase €105.00
1545 AZ 628 B-Raf and C-Raf protein kinase inhibitor €80.00
1778 AZ 960 JAK2 inhibitor €95.00
2171 AZD 1080 Selective inhibitor of GSK-3α and GSK-3β €110.00
2795 AZD 1208 Pim kinase inhibitor €70.00
1464 AZD 2281 PARP inhibitor €55.00
2241 AZD 2461 PARP inhibitor with poor P-glycoprotein substrate qualities €105.00
2194 AZD 2858 hydrochloride Potent and highly selective Glycogen Synthase Kinase-3β inhibitor €95.00
2153 AZD 3463 Potent inhibitor of ALK and IGF1R €105.00
2563 AZD 3759 Potent, orally active, brain-penetrant, EGFR tyrosine kinase inhibitor €85.00
1859 AZD 5363 dihydrochloride Inhibitor of protein kinase B (Akt) €110.00
1966 AZD 5438 CDK inhibitor (1, 2, and 9 specific) €80.00
1516 AZD 6244 MEK1 and MEK2 inhibitor €70.00

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