Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
3690 AZD8186 PI3Kβ/δ isoform-selective inhibitor Inquire
2981 B106 Potent and selective PKC-δ inhibitor €135.00
3055 B591 Potent, specific class I PI3K inhibitor €125.00
1282 BAG 956 PI3K and PDPK1 inhibitor €95.00
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €90.00
2774 Barbadin β-Arrestin/β2-Adaptin inhibitor €110.00
1955 Baricitinib Inhibitor of JAK1 and JAK2 €70.00
2132 BAY 11-7082 IKK inhibitor and anti-inflammatory €85.00
2918 BAY 1895344 Potent, orally available and highly selective inhibitor of ATR protein kinase €100.00
3598 BAY-091 hydrochloride First potent and highly selective PIP4K2A inhibitor  Recently added €180.00
3053 BAY-293 Potent, selective and cell-active inhibitor of KRAS-SOS1 interaction €140.00
3211 BC1618 Potent, orally bioavailable, and metabolically stable Fbxo48 inhibitor €120.00
2178 BCI Allosteric inhibitor of dual-specificity phosphatases (DUSP) €75.00
2852 BCI hydrochloride Allosteric inhibitor of dual-specificity phosphatases (DUSP) €75.00
3115 Belinostat HDAC inhibitor €70.00
3067 Belvarafenib Orally bioavailable pan-Raf protein kinase inhibitor €115.00
3760 Belzutifan Second-generation potent, selective and orally active HIF-2α inhibitor  Recently added €280.00
2002 Bentamapimod JNK inhibitor, which inhibited JNK1, JNK2 and JNK3 €70.00
1281 BEZ 235 PI3K and mTOR tyrosine kinase inhibitor €50.00
3397 BG45 HDAC inhibitor (1, 2, 3 Selective) €80.00
3471 BI-3406 Inhibitor of KRAS/Son of Sevenless 1 (SOS1) interaction  Recently added Inquire
3361 BI-3802 Highly potent and efficacious BCL6 degrader €130.00
1528 BI-D1870 RSK inhibitor (p90 RSK specific) €80.00
3295 BIA TMBIM6 antagonist €120.00
2301 BIBR 1532 Potent and selective telomerase inhibitor inducing senescence in human cancer cells. €70.00
1544 BIBW 2992 EGFR and ErbB-2/HER2 tyrosine kinase inhibitor €50.00
3697 Binimetinib Potent, selective, non-ATP-competitive and orally available allosteric inhibitor of MEK1/2  Recently added €60.00
1693 BIO GSK-3 inhibitor €95.00
1358 BIRB 796 MAPK inhibitor (p38 specific) €65.00
1809 BIX 02189 MEK5 inhibitor; ERK5 inhibitor €110.00

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