Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
2307 ARM1 hydrobromide Novel type of LTA4H inhibitor that selectively blocks the conversion of LTA4 into LTB4 €92.00
1992 AS 1517499 Potent and selective STAT6 inhibitor €135.00
2839 AS 1842856 Inhibitor of the Forkhead box protein O1 (FOXO1) €95.00
2187 AS 1892802 Potent, selective, ATP-competitive ROCK inhibitor €95.00
1424 AS 252424 PI3K inhibitor (p110-γ specific) €85.00
1436 AS 252424 bispotassium salt PI3K inhibitor (p110-γ specific) €95.00
2002 AS 602801 JNK inhibitor, which inhibited JNK1, JNK2 and JNK3 €120.00
2179 ASK1 Inhibitor 10 Potent, selective, and orally bioavailable ASK1 inhibitor €125.00
2005 ASP 3026 Inhibitor of the oncogenic fusion kinase EML4-ALK €80.00
1986 AST 1306 tosylate ErbB2 and EGFR inhibitor €105.00
2166 AT 13148 dihydrochloride ATP-competitive inhibitor of multi-AGC kinases €85.00
1539 AT 7519 mesylate CDK inhibitor €80.00
2219 AT 9283 Multitargeted kinase inhibitor (Aurora A/B, JAK2/3, and BCR-Abl) €85.00
2748 Autophinib PIK3C3/Vps34 inhibitor €120.00
5051 Axon Ligands™ Cell signaling and Oncology compound library Axon Ligands™ Cell signaling and Oncology compound library Inquire

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