Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
1986 AST 1306 tosylate ErbB2 and EGFR inhibitor €105.00
2563 AZD 3759 Potent, orally active, brain-penetrant, EGFR tyrosine kinase inhibitor €85.00
2342 AZD 9291 Potent oral, irreversible, third-generation EGFR TKI with selectivity for mutant EGFRs €95.00
1433 CI 1033 EGFR tyrosine kinase inhibitor €60.00
2680 EAI045 Allosteric EGFR inhibitor (L858R/T790M-specific) €105.00
1760 EGFR Inhibitor [879127-07-8] Highly selective EGFR tyrosine kinase inhibitor €125.00
1128 Erlotinib hydrochloride EGFR tyrosine kinase inhibitor €70.00
1393 Gefitinib EGFR tyrosine kinase inhibitor €70.00
2955 NSC 228155 EGFR tyrosine kinase activator; Inhibitor of KIX-KID interaction  Recently added €75.00
1632 OSI 420 EGFR tyrosine kinase inhibitor €90.00
1665 Pelitinib EGFR tyrosine kinase inhibitor €95.00
1506 WZ 4002 EGFR kinase inhibitor (T790M specific) €70.00

12 Item(s)

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