Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
2222 10058-F4 c-Myc inhibitor inducing cell-cycle arrest at G0/G1 phase €80.00
1593 ABT 888 PARP inhibitor €55.00
2888 ABT 888 dihydrochloride PARP inhibitor  Recently added €95.00
1529 AG 014699 PARP1 inhibitor €75.00
1496 Aminobenzamide, 3- Competitive small molecule inhibitor of PARP €45.00
1992 AS 1517499 Potent and selective STAT6 inhibitor €135.00
2839 AS 1842856 Inhibitor of the Forkhead box protein O1 (FOXO1) €95.00
1464 AZD 2281 PARP inhibitor €55.00
2241 AZD 2461 PARP inhibitor with poor P-glycoprotein substrate qualities €105.00
1399 AZD 7762 hydrochloride CHK inhibitor €60.00
2301 BIBR 1532 Potent and selective telomerase inhibitor inducing senescence in human cancer cells. €70.00
2462 BMH 21 Inhibitor of RNA Polymerase I (RNAP1) €95.00
2699 CCT251236 HSF1 stress pathway inhibitor €145.00
1611 CGP 57380 Mnk1 inhibitor €95.00
1636 CHIR 124 CHK1 inhibitor €65.00

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