Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

11 Item(s)

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Axon ID Name Description From price
1539 AT 7519 mesylate CDK inhibitor €80.00
1966 AZD 5438 CDK inhibitor (1, 2, and 9 specific) €80.00
2273 LEE 011 Orally bioavailable and highly selective small-molecule inhibitor of CDK4/6 €85.00
2695 NSC 23005 sodium Novel small molecule inhibitor of INK4C (p18(INK4C) or p18) €90.00
1243 NSC 625987 CDK4 inhibitor €95.00
2052 Palbociclib isethionate Orally active cyclin-dependent kinase (CDK4/6) inhibitor €125.00
1505 PD 0332991 hydrochloride CDK4 and CDK6 inhibitor €85.00
1983 R 547 CDK inhibitor (1, 2, and 4 specific) €95.00
1530 RO 3306 CDK1 inhibitor €90.00
1776 SCH 727965 CDK inhibitor (1, 2, 5, and 9 specific) €105.00
1614 SNS 032 CDK inhibitor (2, 7 and 9 specific) €85.00

11 Item(s)

per page
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