Signaling Pathways
A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]
[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
1810 | Bortezomib | Inhibitor of 26S proteasome | €80.00 | |
2935 | COH000 | First-in-class, highly specific, covalent allosteric inhibitor of SUMO E1 | €175.00 | |
1798 | Eeyarestatin I | Inhibitor of endoplasmic reticulum associated protein degradation (ERAD) | €80.00 | |
3426 | IU1-47 | Potent and selective inhibitor deubiquitinase USP14 | €80.00 | |
2449 | LDN 57444 | Reversible, competitive inhibitor of UCH-L1 deubiquitinase | €95.00 | |
1869 | MG 132 | Inhibitor of 26S proteasome | €80.00 | |
2309 | ML 323 | Selective, reversible and potent inhibitor of the USP1–UAF1 deubiquitinase complex | €95.00 | |
2995 | ML 367 | Inhibitor of ATAD5 stabilization | €125.00 | |
3109 | ML-792 | Potent and selective inhibitor of SUMO-activating enzyme (SAE) | €145.00 | |
2678 | ML364 | Inhibitor of the deubiquitinase USP2 | €125.00 | |
2556 | MLN 2238 | Selective and reversible 20S proteasome inhibitor | €85.00 | |
2557 | MLN 9708 | Citrate prodrug of MLN 2238, selective and reversible 20S proteasome inhibitor | €95.00 | |
2565 | N106 | Activator of E1 ligase mediated SERCA2a SUMOylation | €95.00 | |
2228 | NSC 687852 | Inhibitor of 19S regulatory-particle–associated deubiquitinases (DUBs: UCHL5 and USP14) | €90.00 | |
2199 | ONX 0914 | Selective inhibitor of LMP7 subunit of the immunoproteasome. | €70.00 | |
2011 | P 005091 | Inhibitor of deubiquitinase USP7 and USP47 | €95.00 | |
1906 | P 22077 | Inhibitor of deubiquitinase USP7 and USP47 | €95.00 | |
1953 | PRT 4165 | E3 Ubiquitin ligase Bmi1/Ring1A inhibitor | €70.00 | |
1904 | SMER 3 | Inhibitor of an SCF family E3 Ubiquitin ligase | €90.00 | |
2512 | Spautin 1 | Inhibitor of USP10 and USP13 and Beclin1 related autophagy | €95.00 | |
3608 | STD1T | Inhibitor of the deubiquitinase USP2a | €160.00 | |
2333 | TCID | Potent inhibitor of UCHL3 with >100-fold selectivity over UCHL1 | €80.00 | |
2991 | USP7-USP47 inhibitor | Selective inhibitor of deubiquitinase USP7 and USP47 | €90.00 | |
1779 | WP 1130 | Deubiquitinase Inhibitor | €95.00 | |
2984 | WS-383 | Highly potent, selective, and cellular active inhibitor of DCN1-UBC12 protein-protein interaction | €125.00 |