Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

29 Item(s)

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Axon ID Name Description From price
2496 2,5-Dimethylcelecoxib Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity €75.00
2153 AZD 3463 Potent inhibitor of ALK and IGF1R €105.00
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €90.00
3295 BIA TMBIM6 antagonist €120.00
2978 Brigatinib Potent, selective, and orally active anaplastic lymphoma kinase (ALK) inhibitor €80.00
3431 BTSA1 Potent activator of proapoptotic BAX €110.00
1884 CH 5424802 Orally available and selective ALK inhibitor €80.00
1863 CID 5951923 Inhibitor of Krüppel-like factor 5 (KLF5) €135.00
3035 Compound 10

Tool compound targeting the NFAT:AP-1 transcriptional complex on DNA.

€150.00
2879 CP 31398 Stabilizer of p53 and inducer of apoptosis €95.00
3518 DCZ0805 NF-κB activation inhibitor  Recently added €130.00
2080 EVP 4593 NF-κB activation inhibitor; inhibits SOC pathway €110.00
2349 JSH 23 Inhibitor of NF-κB transcription and nuclear translocation of p65 without affecting IκBα degradation €95.00
3441 KL001 Cryptochrome stabilizer €120.00
2224 LDK 378 Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor €95.00
3270 Lj-1-60 Fyn inhibitor targeting the Fyn/Stat3 pathway €90.00
3607 Micheliolide NF-κB activation inhibitor €120.00
3387 NF-κB Activation Inhibitor IV Potent NF-κB activation inhibitor €90.00
3277 NSC194598 p53 DNA-binding inhibitor €130.00
1416 NVP-TAE684 NPM-ALK inhibitor €50.00
3614 Parthenolide NF-κB activation inhibitor €90.00
2600 PF 06463922 Potent, orally available and brain-penetrant ALK/ROS1 selective inhibitor €105.00
1871 Pifithrin-α hydrobromide Inhibitor of p53 protein €95.00
3051 Pifithrin-β Inhibitor of p53 protein; Condensation product of Pifithrin-α €95.00
3520 PY108 Potent, orally bioavailable AHR agonist €120.00
3521 PY109 Potent, orally bioavailable AHR agonist €120.00
2627 SMER 28 Small molecule enhancer of rapamycin that enhances autophagy €80.00
1865 Stemregenin 1 Aryl hydrocarbon receptor (AHR) antagonist €105.00
2385 WZ 4003 Specific dual inhibitor of NUAK1 (ARK5) and NUAK2 (SNARK) €80.00

29 Item(s)

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