Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
2153 AZD 3463 Potent inhibitor of ALK and IGF1R €105.00
2185 BAM 7 Selective small-molecule activator of proapoptotic BAX €105.00
2978 Brigatinib Potent, selective, and orally active anaplastic lymphoma kinase (ALK) inhibitor  Recently added €80.00
1884 CH 5424802 Orally available and selective ALK inhibitor €95.00
1863 CID 5951923 Inhibitor of Krüppel-like factor 5 (KLF5) €135.00
2879 CP 31398 Stabilizer of p53 and inducer of apoptosis €95.00
2496 Dimethylcelecoxib, 2,5- Celecoxib analog with anti-tumor properties, lacking COX-2 inhibitory activity €75.00
2080 EVP 4593 NF-κB activation inhibitor; inhibits SOC pathway €110.00
2349 JSH 23 Inhibitor of NF-κB transcription and nuclear translocation of p65 without affecting IκBα degradation €95.00
2224 LDK 378 Potent, bioavailable, and selective anaplastic lymphoma kinase (ALK) inhibitor €95.00
1416 NVP-TAE684 NPM-ALK inhibitor €70.00
2600 PF 06463922 Potent, orally available and brain-penetrant ALK/ROS1 selective inhibitor €105.00
1871 Pifithrin-α hydrobromide Inhibitor of p53 protein €95.00
2627 SMER 28 Small molecule enhancer of rapamycin that enhances autophagy €80.00
1865 Stemregenin 1 Aryl hydrocarbon receptor (AHR) antagonist €105.00

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