Signaling Pathways
A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]
[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.
Axon ID | Name | Description | From price | |
---|---|---|---|---|
2639 | AMG 232 | Potent, selective, and orally bioavailable MDM2-p53 inhibitor | €120.00 | |
3765 | DS-3032 | Orally available, potent and selective inhibitor of the p53-MDM2 interaction | Inquire | |
1643 | HLI 373 | HDM2 inhibitor | €100.00 | |
1538 | JNJ 26854165 | HDM2 inhibitor | €105.00 | |
1586 | JNJ 26854165 dihydrochloride | HDM2 inhibitor | €105.00 | |
1585 | Nutlin-3 | MDM2 inhibitor (p53 specific) | €95.00 | |
1880 | Nutlin-3a | Inhibitor of MDM2 | €95.00 | |
1881 | Nutlin-3b | Less potent (+)-enantiomer of Nutlin-3 | €90.00 | |
3751 | NVP-CGM097 | Inhibitor of MDM2 | Inquire | |
3752 | NVP-CGM097 dihydrochloride | Inhibitor of MDM2 | Inquire | |
4035 | RG-7388 | Potent and selective MDM2 antagonist | Inquire | |
2009 | RITA | Activates p53 through inhibition of MDM2 | €105.00 | |
2741 | SAR405838 | MDM2-p53 inhibitor | €125.00 | |
3737 | Siremadlin | Potent, selective, and orally bioavailable MDM2-p53 inhibitor | €130.00 | |
2164 | SJ 172550 | Small molecule inhibitor of MDMX | €95.00 | |
2437 | SP 141 | Specific MDM2 inhibitor with therapeutic effects in breast cancer models | €120.00 |