Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

15 Item(s)

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Axon ID Name Description From price
1378 AG 490 JAK2 inhibitor €65.00
1778 AZ 960 JAK2 inhibitor €95.00
1955 Baricitinib Inhibitor of JAK1 and JAK2 €90.00
1338 CP 690550 JAK3 inhibitor €65.00
1681 CYT 387 JAK1 and JAK2 inhibitor €90.00
1843 JAK2 inhibitor 13 JAK2 inhibitor €105.00
2554 LY 2784544 Potent, selective and ATP-competitive inhibitor of mutated janus kinase 2 (JAK2V617F) €95.00
2792 NVP-BSK805 Potent, selective and orally bioavailable JAK2 inhibitor €125.00
2217 PF 956980 JAK3 inhibitor; analogue of Axon 1338 and 2072 €90.00
1598 Ruxolitinib JAK1 and JAK2 inhibitor €70.00
2539 Solcitinib Selective JAK1 inhibitor for treatment of degenerative and inflammatory diseases €90.00
1588 TG 101348 JAK2 inhibitor €95.00
2072 Tofacitinib citrate Potent Janus Kinase 3 (JAK3) inhibitor €115.00
2316 WP 1066 Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins €95.00
2231 XL 019 JAK2 inhibitor €100.00

15 Item(s)

per page
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