Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
1527 XAV 939 Tankyrase (TNKS) inhibitor €80.00
2385 WZ 4003 Specific dual inhibitor of NUAK1 (ARK5) and NUAK2 (SNARK) €80.00
1506 WZ 4002 EGFR kinase inhibitor (T790M specific) €70.00
2984 WS-383 Highly potent, selective, and cellular active inhibitor of DCN1-UBC12 protein-protein interaction €125.00
1779 WP 1130 Deubiquitinase Inhibitor €95.00
2316 WP 1066 Potent JAK2 and STAT3 inhibitor and downregulator of antiapoptotic proteins €95.00
2287 Wnt-C59 Highly potent porcupine (Porcn) inhibitor €75.00
2120 Wnt agonist 1 Wnt/β-catenin signaling pathway agonist or activator €90.00
2381 WH-4-023 Orally active src-family selective lck inhibitor €90.00
2325 WAY 316606 hydrochloride Potent inhibitor of sFRP-1 that stimulates Wnt signaling €85.00
2188 WAY 262611 dihydrochloride Inhibitor of Dickkopf-1 (DKK1); Wnt/β-Catenin signaling agonist €125.00
1811 VX 745 Inhibitor of p38α MAP kinase €90.00
3114 Vorinostat HDAC inhibitor €45.00
2810 VH298 Inhibitor of E3 ubiquitin-protein ligase VHL €135.00
2452 VE 822 Selective ATR inhibitor that decreases survival of pancreatic cancer cells €110.00

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