Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
2469 YK 4-279 Inhibitor of ETV1, ERG and interactions of EWS-FLI1 and RNA helicase A €95.00
2268 XL 413 hydrochloride Potent, selective and orally bioavailable CDC7 inhibitor €120.00
1527 XAV 939 Tankyrase (TNKS) inhibitor €80.00
2369 UPF 1069 PARP-2 inhibitor with >26 fold selectivity over PARP1 €75.00
2100 Trovafloxacin mesylate Inhibitor of bacterial DNA gyrase and Topo IV €95.00
2914 TAS-103 dihydrochloride Dual inhibitor of topoisomerase I (Topo 1) and topoisomerase II (Topo 2) €95.00
2502 Talazoparib Potent, selective, and orally available PARP1/2 inhibitor €105.00
2314 Stattic Nonpeptidic small-molecule inhibitor of STAT3 activation, dimerization, and nuclear translocation €50.00
2731 STAT5 Inhibitor 1 [285986-31-4] Nonpeptidic small-molecule inhibitor of STAT5 activation €90.00
2200 SRPIN 340 Selective ATP-competitive inhibitor of SRPK kinase activity €95.00
2764 SIS3 Potent and selective inhibitor of Smad3 and TGF-βR1 signaling €135.00
2531 SCR7 pyrazine DNA ligase IV mediated inhibitor of NHEJ €65.00
2244 SCH 529074 Small molecule activator of mutant p53. €100.00
2313 S3I 201 Potent, cellular STAT3 inhibitor €95.00
2497 RTA 408 Triterpenoid activator of NRF2 and inhibitor of NF-κB €110.00

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