Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
1386 CHIR 99021 GSK-3 inhibitor €60.00
1126 CHIR 98014 GSK-3 inhibitor €95.00
3069 CCG-222740 Potent and selective Rho/MRTF/SRF transcriptional pathway inhibitor €145.00
3092 CCG-203971 Rho/MRTF/SRF transcriptional pathway inhibitor €60.00
2753 CCG 232601 Rho/MRTF/SRF transcriptional pathway inhibitor €160.00
3153 BRD5648 Negative control compound of BRD0705 as a GSK3α inhibitor €210.00
2931 BRD0705 First-in-class, paralog selective GSK3α inhibitor €210.00
1693 BIO GSK-3 inhibitor €95.00
1544 BIBW 2992 EGFR and ErbB-2/HER2 tyrosine kinase inhibitor €50.00
2981 B106 Potent and selective PKC-δ inhibitor €135.00
2194 AZD 2858 hydrochloride Potent and highly selective Glycogen Synthase Kinase-3β inhibitor €95.00
2795 AZD 1208 Pim kinase inhibitor €70.00
2171 AZD 1080 Selective inhibitor of GSK-3α and GSK-3β €110.00
5053 Axon Ligands™ Stem cell compound library Axon Ligands™ Stem cell compound library Inquire
5051 Axon Ligands™ Cell signaling and Oncology compound library Axon Ligands™ Cell signaling and Oncology compound library Inquire

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