Signaling Pathways

Axon Ligands™ for research on Signaling Pathways

A basic property of living systems is the ability to respond to extracellular signals by evoking an internal response. Signal-transduction cascades mediate the sensing and processing of these stimuli. These molecular circuits detect, amplify, and integrate diverse external signals to generate responses such as changes in enzyme activity, gene expression, phenotypic alterations, or ion-channel activity. Signal-transduction pathways follow a broadly similar course that can be viewed as a molecular circuit. Upon an environmental signal, Membrane receptors transfer information from the environment to the cell's interior. Subsequently, second messengers relay information from the receptor-ligand complex into the cell's interior. Particularly important second messengers include cyclic AMP and cyclic GMP, calcium ion, inositol 1,4,5-trisphosphate, (IP3), and diacylglycerol. While these second messengers are free to move, they can easily diffuse to other compartments of the cell, such as the nucleus, where they can influence gene expression and other processes. Interestingly, signal transduction may be amplified significantly in the generation of second messengers, since initial stimulation may lead to the generation of many second messengers within the cell. Thus, a low concentration of signal in the environment, even as little as a single molecule, can yield a large intracellular signal and response. Besides this phenomenon, cross-talk between two or more signaling cascades may occur, which permits more finely tuned regulation of cell activity than would the action of individual independent pathways[1]


[1] Signal-Transduction Pathways: An Introduction to Information Metabolism. Biochemistry. 5th edition. J.M. Berg, J.L.Tymoczko, L. Stryer.New York, 2002.

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Axon ID Name Description From price
1633 SGI 1776 free base Pim kinase inhibitor €95.00
1303 SB 216763 GSK-3 inhibitor €85.00
2229 RKI 1447 Potent inhibitor of the Rho-associated ROCK kinases €105.00
2677 RIPA-56 RIP1 inhibitor for the treatment of systemic inflammatory response syndrome €60.00
2920 Poziotinib Irreversible pan-HER inhibitor €95.00
2459 PND 1186 Orally active dual FAK/PYK2 inhibitor triggering cell apoptosis in tumor cells €105.00
1792 PF 4800567 Inhibitor of Casein kinase 1 (CK1-ε) €95.00
2546 PF 06447475 Potent, selective, brain penetrant, and in vivo active LRRK2 kinase inhibitor €85.00
1137 PD 180970 Bcr-Abl tyrosine kinase inhibitor (p210 specific) €120.00
1396 Nilotinib BCR-ABL inhibitor €70.00
1526 Neratinib EGFR and ErbB-2/HER2 tyrosine kinase inhibitor €90.00
1258 Necrostatin-1 RIP1 inhibitor €95.00
5010 Naive Stem Cell NHSM inhibitor Set Set of inhibitors for isolation, generation, derivatization and stabilization of naive hPSCs €260.00
5011 Naive Stem Cell 5i inhibitor Set Set of five inhibitors for the induction and maintenance of human naive stem cell pluripotency €220.00
1401 LY 333531 mesylate PKC-β inhibitor €75.00

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